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No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise

Physical exercise results in structural remodeling in tissues and modifies cellular metabolism. Changes in gene expression lie at the root of these adaptations. Epigenetic changes are one of the factors responsible for such exercise-related alterations. One-hour acute exercise will change DNMT1, HDA...

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Autores principales: Światowy, Witold Józef, Zieliński, Jacek, Osielska, Maria Aleksandra, Kusy, Krzysztof, Wieliński, Dariusz, Pławski, Andrzej, Jagodziński, Paweł Piotr
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836983/
https://www.ncbi.nlm.nih.gov/pubmed/36352208
http://dx.doi.org/10.1007/s13353-022-00736-6
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author Światowy, Witold Józef
Zieliński, Jacek
Osielska, Maria Aleksandra
Kusy, Krzysztof
Wieliński, Dariusz
Pławski, Andrzej
Jagodziński, Paweł Piotr
author_facet Światowy, Witold Józef
Zieliński, Jacek
Osielska, Maria Aleksandra
Kusy, Krzysztof
Wieliński, Dariusz
Pławski, Andrzej
Jagodziński, Paweł Piotr
author_sort Światowy, Witold Józef
collection PubMed
description Physical exercise results in structural remodeling in tissues and modifies cellular metabolism. Changes in gene expression lie at the root of these adaptations. Epigenetic changes are one of the factors responsible for such exercise-related alterations. One-hour acute exercise will change DNMT1, HDAC1, and JHDM1D transcriptions in PBMC. This study examined changes in the expression of genes responsible for epigenetic modifications (HDAC1, DNMT1, and JHDM1D) during and after an incremental exercise test on a treadmill and a 30-min recovery. Blood samples from 9 highly trained triathletes were tested. Examination of the transcripts showed no significant changes. Correlations between transcript results and biochemical indices revealed a significant (p = 0.007) relationship between JHDM1D mRNA and the number of monocytes at peak exercise intensity (exhaustion), while there was no significant (p = 0.053) correlation at rest. There are no rapid changes in the mRNA levels of the genes studied in blood cells in competitive athletes during acute exercise and recovery. Due to the small group of subjects studied, more extensive research is needed to verify correlations between transcription and biochemical variables. 
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spelling pubmed-98369832023-01-14 No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise Światowy, Witold Józef Zieliński, Jacek Osielska, Maria Aleksandra Kusy, Krzysztof Wieliński, Dariusz Pławski, Andrzej Jagodziński, Paweł Piotr J Appl Genet Human Genetics • Original Paper Physical exercise results in structural remodeling in tissues and modifies cellular metabolism. Changes in gene expression lie at the root of these adaptations. Epigenetic changes are one of the factors responsible for such exercise-related alterations. One-hour acute exercise will change DNMT1, HDAC1, and JHDM1D transcriptions in PBMC. This study examined changes in the expression of genes responsible for epigenetic modifications (HDAC1, DNMT1, and JHDM1D) during and after an incremental exercise test on a treadmill and a 30-min recovery. Blood samples from 9 highly trained triathletes were tested. Examination of the transcripts showed no significant changes. Correlations between transcript results and biochemical indices revealed a significant (p = 0.007) relationship between JHDM1D mRNA and the number of monocytes at peak exercise intensity (exhaustion), while there was no significant (p = 0.053) correlation at rest. There are no rapid changes in the mRNA levels of the genes studied in blood cells in competitive athletes during acute exercise and recovery. Due to the small group of subjects studied, more extensive research is needed to verify correlations between transcription and biochemical variables.  Springer Berlin Heidelberg 2022-11-10 2023 /pmc/articles/PMC9836983/ /pubmed/36352208 http://dx.doi.org/10.1007/s13353-022-00736-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Human Genetics • Original Paper
Światowy, Witold Józef
Zieliński, Jacek
Osielska, Maria Aleksandra
Kusy, Krzysztof
Wieliński, Dariusz
Pławski, Andrzej
Jagodziński, Paweł Piotr
No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise
title No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise
title_full No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise
title_fullStr No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise
title_full_unstemmed No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise
title_short No dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise
title_sort no dynamic changes in the expression of genes related to the epigenetic mechanism during acute exercise
topic Human Genetics • Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9836983/
https://www.ncbi.nlm.nih.gov/pubmed/36352208
http://dx.doi.org/10.1007/s13353-022-00736-6
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