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Photobiomodulation for Alzheimer’s disease: photoelectric coupling effect on attenuating Aβ neurotoxicity

Alzheimer’s disease (AD) and dementia are the most worrying health problems faced by people globally today. Although the pathological features of AD consisting of amyloid-beta (Aβ) plaques in the extracellular space (ECS) and intracellular tau tangles are well established, the developed medicines ta...

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Autores principales: Tian, Zixi, Wang, Panpan, Huang, Kai, Yu, Jie, Zhang, Mange, Liu, Yanming, Zhao, Hang, Zhu, Beilei, Huang, Xuerong, Tong, Zhiqian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer London 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837011/
https://www.ncbi.nlm.nih.gov/pubmed/36633696
http://dx.doi.org/10.1007/s10103-022-03692-z
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author Tian, Zixi
Wang, Panpan
Huang, Kai
Yu, Jie
Zhang, Mange
Liu, Yanming
Zhao, Hang
Zhu, Beilei
Huang, Xuerong
Tong, Zhiqian
author_facet Tian, Zixi
Wang, Panpan
Huang, Kai
Yu, Jie
Zhang, Mange
Liu, Yanming
Zhao, Hang
Zhu, Beilei
Huang, Xuerong
Tong, Zhiqian
author_sort Tian, Zixi
collection PubMed
description Alzheimer’s disease (AD) and dementia are the most worrying health problems faced by people globally today. Although the pathological features of AD consisting of amyloid-beta (Aβ) plaques in the extracellular space (ECS) and intracellular tau tangles are well established, the developed medicines targeting these two proteins have not obtained the expected clinical effects. Photobiomodulation (PBM) describes the therapeutic use of red light (RL) or near-infrared light (NIR) to serve as a noninvasive neuroprotective strategy for brain diseases. The present review discusses the mechanisms of the photoelectric coupling effect (light energy-induced special electronic transition-related alterations in protein structure) of PBM on reducing Aβ toxicity. On the one hand, RL or NIR can directly disassemble Aβ in vitro and in vivo. On the other hand, formaldehyde (FA)-inhibited catalase (CAT) and H(2)O(2)-inactived formaldehyde dehydrogenase (FDH) are formed a vicious circle in AD; however, light energy not only activates FDH to degrade excessive FA (which crosslinks Aβ monomer to form Aβ oligomers and senile plaques) but also sensitizes CAT to reduce hydrogen peroxide levels (H(2)O(2), which can facilitate Aβ aggregation and enhance FA generation). In addition, it also activates mitochondrial cytochrome-c to produce ATP in the neurons. Clinical trials of phototherapeutics or oral coenzyme Q10 have shown positive effects in AD patients. Hence, a promising strategy combined PBM with nanopacked Q10 has been proposed to apply for treating AD.
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spelling pubmed-98370112023-01-14 Photobiomodulation for Alzheimer’s disease: photoelectric coupling effect on attenuating Aβ neurotoxicity Tian, Zixi Wang, Panpan Huang, Kai Yu, Jie Zhang, Mange Liu, Yanming Zhao, Hang Zhu, Beilei Huang, Xuerong Tong, Zhiqian Lasers Med Sci Review Article Alzheimer’s disease (AD) and dementia are the most worrying health problems faced by people globally today. Although the pathological features of AD consisting of amyloid-beta (Aβ) plaques in the extracellular space (ECS) and intracellular tau tangles are well established, the developed medicines targeting these two proteins have not obtained the expected clinical effects. Photobiomodulation (PBM) describes the therapeutic use of red light (RL) or near-infrared light (NIR) to serve as a noninvasive neuroprotective strategy for brain diseases. The present review discusses the mechanisms of the photoelectric coupling effect (light energy-induced special electronic transition-related alterations in protein structure) of PBM on reducing Aβ toxicity. On the one hand, RL or NIR can directly disassemble Aβ in vitro and in vivo. On the other hand, formaldehyde (FA)-inhibited catalase (CAT) and H(2)O(2)-inactived formaldehyde dehydrogenase (FDH) are formed a vicious circle in AD; however, light energy not only activates FDH to degrade excessive FA (which crosslinks Aβ monomer to form Aβ oligomers and senile plaques) but also sensitizes CAT to reduce hydrogen peroxide levels (H(2)O(2), which can facilitate Aβ aggregation and enhance FA generation). In addition, it also activates mitochondrial cytochrome-c to produce ATP in the neurons. Clinical trials of phototherapeutics or oral coenzyme Q10 have shown positive effects in AD patients. Hence, a promising strategy combined PBM with nanopacked Q10 has been proposed to apply for treating AD. Springer London 2023-01-12 2023 /pmc/articles/PMC9837011/ /pubmed/36633696 http://dx.doi.org/10.1007/s10103-022-03692-z Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article
Tian, Zixi
Wang, Panpan
Huang, Kai
Yu, Jie
Zhang, Mange
Liu, Yanming
Zhao, Hang
Zhu, Beilei
Huang, Xuerong
Tong, Zhiqian
Photobiomodulation for Alzheimer’s disease: photoelectric coupling effect on attenuating Aβ neurotoxicity
title Photobiomodulation for Alzheimer’s disease: photoelectric coupling effect on attenuating Aβ neurotoxicity
title_full Photobiomodulation for Alzheimer’s disease: photoelectric coupling effect on attenuating Aβ neurotoxicity
title_fullStr Photobiomodulation for Alzheimer’s disease: photoelectric coupling effect on attenuating Aβ neurotoxicity
title_full_unstemmed Photobiomodulation for Alzheimer’s disease: photoelectric coupling effect on attenuating Aβ neurotoxicity
title_short Photobiomodulation for Alzheimer’s disease: photoelectric coupling effect on attenuating Aβ neurotoxicity
title_sort photobiomodulation for alzheimer’s disease: photoelectric coupling effect on attenuating aβ neurotoxicity
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837011/
https://www.ncbi.nlm.nih.gov/pubmed/36633696
http://dx.doi.org/10.1007/s10103-022-03692-z
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