A specific G9a inhibitor unveils BGLT3 lncRNA as a universal mediator of chemically induced fetal globin gene expression

Sickle cell disease (SCD) is a heritable disorder caused by β-globin gene mutations. Induction of fetal γ-globin is an established therapeutic strategy. Recently, epigenetic modulators, including G9a inhibitors, have been proposed as therapeutic agents. However, the molecular mechanisms whereby thes...

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Detalles Bibliográficos
Autores principales: Takase, Shohei, Hiroyama, Takashi, Shirai, Fumiyuki, Maemoto, Yuki, Nakata, Akiko, Arata, Mayumi, Matsuoka, Seiji, Sonoda, Takeshi, Niwa, Hideaki, Sato, Shin, Umehara, Takashi, Shirouzu, Mikako, Nishigaya, Yosuke, Sumiya, Tatsunobu, Hashimoto, Noriaki, Namie, Ryosuke, Usui, Masaya, Ohishi, Tomokazu, Ohba, Shun-ichi, Kawada, Manabu, Hayashi, Yoshihiro, Harada, Hironori, Yamaguchi, Tokio, Shinkai, Yoichi, Nakamura, Yukio, Yoshida, Minoru, Ito, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837035/
https://www.ncbi.nlm.nih.gov/pubmed/36635268
http://dx.doi.org/10.1038/s41467-022-35404-0

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