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A non-catalytic N-terminus domain of WRN prevents mitotic telomere deprotection
Telomeric ends form a loop structure (T-loop) necessary for the repression of ATM kinase activation throughout the normal cell cycle. However, cells undergoing a prolonged mitotic arrest are prone to lose the T-loop, resulting in Aurora B kinase-dependent mitotic telomere deprotection, which was pro...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Nature Publishing Group UK
2023
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837040/ https://www.ncbi.nlm.nih.gov/pubmed/36635307 http://dx.doi.org/10.1038/s41598-023-27598-0 |