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Large-scale genomic analysis of Mycobacterium tuberculosis reveals extent of target and compensatory mutations linked to multi-drug resistant tuberculosis

Resistance to isoniazid (INH) and rifampicin (RIF) first-line drugs in Mycobacterium tuberculosis (Mtb), together called multi-drug resistance, threatens tuberculosis control. Resistance mutations in katG (for INH) and rpoB (RIF) genes often come with fitness costs. To overcome these costs, Mtb comp...

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Detalles Bibliográficos
Autores principales:	Napier, Gary, Campino, Susana, Phelan, Jody E., Clark, Taane G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837068/ https://www.ncbi.nlm.nih.gov/pubmed/36635309 http://dx.doi.org/10.1038/s41598-023-27516-4

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