The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen

It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despite the involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able to demonstrate a genetic contribution of genes involved in...

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Autores principales: Clochard, Gwen-Jirō, Mbengue, Aby, Mettling, Clément, Diouf, Birane, Faurie, Charlotte, Sene, Omar, Chancerel, Emilie, Guichoux, Erwan, Hollard, Guillaume, Raymond, Michel, Willinger, Marc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
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Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837182/
https://www.ncbi.nlm.nih.gov/pubmed/36635358
http://dx.doi.org/10.1038/s41598-022-27002-3
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author Clochard, Gwen-Jirō
Mbengue, Aby
Mettling, Clément
Diouf, Birane
Faurie, Charlotte
Sene, Omar
Chancerel, Emilie
Guichoux, Erwan
Hollard, Guillaume
Raymond, Michel
Willinger, Marc
author_facet Clochard, Gwen-Jirō
Mbengue, Aby
Mettling, Clément
Diouf, Birane
Faurie, Charlotte
Sene, Omar
Chancerel, Emilie
Guichoux, Erwan
Hollard, Guillaume
Raymond, Michel
Willinger, Marc
author_sort Clochard, Gwen-Jirō
collection PubMed
description It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despite the involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able to demonstrate a genetic contribution of genes involved in the dopaminergic pathway in risk attitudes and gene candidate studies gave contrasting results. We test the possibility that a genetic effect of the DRD4-7R allele in risk-taking behavior could be modulated by environmental factors. We show that the increase in risk-tolerance due to the 7R allele is independent of the environmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing.
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spelling pubmed-98371822023-01-14 The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen Clochard, Gwen-Jirō Mbengue, Aby Mettling, Clément Diouf, Birane Faurie, Charlotte Sene, Omar Chancerel, Emilie Guichoux, Erwan Hollard, Guillaume Raymond, Michel Willinger, Marc Sci Rep Article It has been shown that living in risky environments, as well as having a risky occupation, can moderate risk-tolerance. Despite the involvement of dopamine in the expectation of reward described by neurobiologists, a GWAS study was not able to demonstrate a genetic contribution of genes involved in the dopaminergic pathway in risk attitudes and gene candidate studies gave contrasting results. We test the possibility that a genetic effect of the DRD4-7R allele in risk-taking behavior could be modulated by environmental factors. We show that the increase in risk-tolerance due to the 7R allele is independent of the environmental risk in two populations in Northern Senegal, one of which is exposed to a very high risk due to dangerous fishing. Nature Publishing Group UK 2023-01-12 /pmc/articles/PMC9837182/ /pubmed/36635358 http://dx.doi.org/10.1038/s41598-022-27002-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Clochard, Gwen-Jirō
Mbengue, Aby
Mettling, Clément
Diouf, Birane
Faurie, Charlotte
Sene, Omar
Chancerel, Emilie
Guichoux, Erwan
Hollard, Guillaume
Raymond, Michel
Willinger, Marc
The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen
title The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen
title_full The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen
title_fullStr The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen
title_full_unstemmed The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen
title_short The effect of the 7R allele at the DRD4 locus on risk tolerance is independent of background risk in Senegalese fishermen
title_sort effect of the 7r allele at the drd4 locus on risk tolerance is independent of background risk in senegalese fishermen
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837182/
https://www.ncbi.nlm.nih.gov/pubmed/36635358
http://dx.doi.org/10.1038/s41598-022-27002-3
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