Genetic conversion of a split-drive into a full-drive element

The core components of CRISPR-based gene drives, Cas9 and guide RNA (gRNA), either can be linked within a self-contained single cassette (full gene-drive, fGD) or be provided in two separate elements (split gene-drive, sGD), the latter offering greater control options. We previously engineered split...

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Detalles Bibliográficos
Autores principales: Terradas, Gerard, Bennett, Jared B., Li, Zhiqian, Marshall, John M., Bier, Ethan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837192/
https://www.ncbi.nlm.nih.gov/pubmed/36635291
http://dx.doi.org/10.1038/s41467-022-35044-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837192/
https://www.ncbi.nlm.nih.gov/pubmed/36635291
http://dx.doi.org/10.1038/s41467-022-35044-4

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