Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies

Erdheim-Chester disease (ECD) is a rare histiocytosis due to proto-oncogene mutations, primarily affecting the long bones and possibly being treated by novel targeted therapies. (18)F-FDG PET is a reference technique for ECD assessment. However, we present a case where easier and more objective moni...

Descripción completa

Detalles Bibliográficos
Autores principales: Melki, Saifeddine, Moulinet, Thomas, Verger, Antoine, Marie, Pierre-Yves, Imbert, Laetitia, Bahloul, Achraf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837338/
https://www.ncbi.nlm.nih.gov/pubmed/36635469
http://dx.doi.org/10.1186/s41824-022-00160-3
_version_ 1784869052088320000
author Melki, Saifeddine
Moulinet, Thomas
Verger, Antoine
Marie, Pierre-Yves
Imbert, Laetitia
Bahloul, Achraf
author_facet Melki, Saifeddine
Moulinet, Thomas
Verger, Antoine
Marie, Pierre-Yves
Imbert, Laetitia
Bahloul, Achraf
author_sort Melki, Saifeddine
collection PubMed
description Erdheim-Chester disease (ECD) is a rare histiocytosis due to proto-oncogene mutations, primarily affecting the long bones and possibly being treated by novel targeted therapies. (18)F-FDG PET is a reference technique for ECD assessment. However, we present a case where easier and more objective monitoring of the ECD-related bone metabolism abnormalities under treatment was obtained with the standardized uptake value-based information provided by fast whole-body [Tc-99 m]-HDP bone tomoscintigraphies (QWBT) recorded with a high-sensitivity CZT-camera/computed tomography (CT) hybrid system. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41824-022-00160-3.
format Online
Article
Text
id pubmed-9837338
institution National Center for Biotechnology Information
language English
publishDate 2023
publisher Springer International Publishing
record_format MEDLINE/PubMed
spelling pubmed-98373382023-01-14 Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies Melki, Saifeddine Moulinet, Thomas Verger, Antoine Marie, Pierre-Yves Imbert, Laetitia Bahloul, Achraf Eur J Hybrid Imaging Case Report Erdheim-Chester disease (ECD) is a rare histiocytosis due to proto-oncogene mutations, primarily affecting the long bones and possibly being treated by novel targeted therapies. (18)F-FDG PET is a reference technique for ECD assessment. However, we present a case where easier and more objective monitoring of the ECD-related bone metabolism abnormalities under treatment was obtained with the standardized uptake value-based information provided by fast whole-body [Tc-99 m]-HDP bone tomoscintigraphies (QWBT) recorded with a high-sensitivity CZT-camera/computed tomography (CT) hybrid system. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41824-022-00160-3. Springer International Publishing 2023-01-13 /pmc/articles/PMC9837338/ /pubmed/36635469 http://dx.doi.org/10.1186/s41824-022-00160-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Case Report
Melki, Saifeddine
Moulinet, Thomas
Verger, Antoine
Marie, Pierre-Yves
Imbert, Laetitia
Bahloul, Achraf
Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies
title Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies
title_full Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies
title_fullStr Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies
title_full_unstemmed Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies
title_short Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies
title_sort targeted therapy monitoring of braf-v600-mutant erdheim-chester disease by fast quantitative whole-body bone czt-tomoscintigraphies
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837338/
https://www.ncbi.nlm.nih.gov/pubmed/36635469
http://dx.doi.org/10.1186/s41824-022-00160-3
work_keys_str_mv AT melkisaifeddine targetedtherapymonitoringofbrafv600mutanterdheimchesterdiseasebyfastquantitativewholebodyboneczttomoscintigraphies
AT moulinetthomas targetedtherapymonitoringofbrafv600mutanterdheimchesterdiseasebyfastquantitativewholebodyboneczttomoscintigraphies
AT vergerantoine targetedtherapymonitoringofbrafv600mutanterdheimchesterdiseasebyfastquantitativewholebodyboneczttomoscintigraphies
AT mariepierreyves targetedtherapymonitoringofbrafv600mutanterdheimchesterdiseasebyfastquantitativewholebodyboneczttomoscintigraphies
AT imbertlaetitia targetedtherapymonitoringofbrafv600mutanterdheimchesterdiseasebyfastquantitativewholebodyboneczttomoscintigraphies
AT bahloulachraf targetedtherapymonitoringofbrafv600mutanterdheimchesterdiseasebyfastquantitativewholebodyboneczttomoscintigraphies

Ejemplares similares