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Optimization of extracellular matrix for primary human hepatocyte cultures using mixed collagen-Matrigel matrices

Loss of differentiation of primary human hepatocytes (PHHs) ex vivo is a known problem of in vitro liver models. Culture optimizations using collagen type I and Matrigel reduce the dedifferentiation process but are not able to prevent it. While neither of these extracellular matrices (ECMs) on their...

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Detalles Bibliográficos
Autores principales:	Seidemann, Lena, Prinz, Sarah, Scherbel, Jan-Constantin, Götz, Christina, Seehofer, Daniel, Damm, Georg
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Leibniz Research Centre for Working Environment and Human Factors 2023
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837384/ https://www.ncbi.nlm.nih.gov/pubmed/36660192 http://dx.doi.org/10.17179/excli2022-5459

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