Conformation of von Willebrand factor in shear flow revealed with stroboscopic single-molecule imaging

von Willebrand factor (VWF) is a multimeric blood protein that acts as a mechanical probe, responding to changes in flow to initiate platelet plug formation. Previously, our laboratory tests had shown that using single-molecule imaging that shear stress can extend surface-tethered VWF, but paradoxic...

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Detalles Bibliográficos
Autores principales: Bergal, Hans T., Jiang, Yan, Yang, Darren, Springer, Timothy A., Wong, Wesley P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Hematology 2022
Materias:
Regular Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837445/
https://www.ncbi.nlm.nih.gov/pubmed/36040485
http://dx.doi.org/10.1182/blood.2022016969

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