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Maternal fluoride exposure, fertility and birth outcomes: The MIREC cohort
OBJECTIVE: Fluoride exposure >1.5 mg/L from water has been associated with adverse pregnancy and birth outcomes. Little is known, however, about the effect of fluoride at levels consistent with water fluoridation (i.e., 0.7 mg/L) on pregnancy and birth outcomes. We examined the relationship betwe...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837859/ https://www.ncbi.nlm.nih.gov/pubmed/36644332 http://dx.doi.org/10.1016/j.envadv.2021.100135 |
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author | Goodman, Carly Hall, Meaghan Green, Rivka Hornung, Richard Martinez-Mier, Esperanza Angeles Lanphear, Bruce Till, Christine |
author_facet | Goodman, Carly Hall, Meaghan Green, Rivka Hornung, Richard Martinez-Mier, Esperanza Angeles Lanphear, Bruce Till, Christine |
author_sort | Goodman, Carly |
collection | PubMed |
description | OBJECTIVE: Fluoride exposure >1.5 mg/L from water has been associated with adverse pregnancy and birth outcomes. Little is known, however, about the effect of fluoride at levels consistent with water fluoridation (i.e., 0.7 mg/L) on pregnancy and birth outcomes. We examined the relationship between maternal fluoride exposure, fertility, and birth outcomes in a Canadian pregnancy cohort living in areas where municipal drinking water fluoride concentrations ranged from 0.04 to 0.87 mg/L. METHODS: Using data from the Maternal-Infant Research on Environmental Chemicals (MIREC) study, we estimated fluoride exposure during pregnancy using three different metrics: (1) maternal urinary fluoride concentrations standardized for specific gravity (MUF(SG)) and averaged across all three trimesters (N = 1566), (2) water fluoride concentration (N = 1370), and (3) fluoride intake based on self-reported consumption of water, coffee, and tea, adjusted for body weight (N = 1192). Data on fertility, birth weight, gestational age, preterm birth, and small-for-gestational age (SGA) were assessed. We used multiple linear regression to examine associations between fluoride exposure, birth weight and gestational age, and logistic regression to examine associations with fertility, preterm birth, and SGA, adjusted for relevant covariates. RESULTS: Median (IQR) MUF(SG) was 0.50 (0.33–0.76) mg/L, median water fluoride was 0.52 (0.17–0.64) mg/L, and median fluoride intake was 0.008 (0.003–0.013) mg/kg/day. MUF(SG), water fluoride concentrations, and fluoride intake were not significantly associated with fertility, birth weight, gestational age, preterm birth, or SGA. Fetal sex did not modify any of the associations. CONCLUSION: Fluoride exposure during pregnancy was not associated with fertility or birth outcomes in this Canadian cohort. |
format | Online Article Text |
id | pubmed-9837859 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
record_format | MEDLINE/PubMed |
spelling | pubmed-98378592023-01-13 Maternal fluoride exposure, fertility and birth outcomes: The MIREC cohort Goodman, Carly Hall, Meaghan Green, Rivka Hornung, Richard Martinez-Mier, Esperanza Angeles Lanphear, Bruce Till, Christine Environ Adv Article OBJECTIVE: Fluoride exposure >1.5 mg/L from water has been associated with adverse pregnancy and birth outcomes. Little is known, however, about the effect of fluoride at levels consistent with water fluoridation (i.e., 0.7 mg/L) on pregnancy and birth outcomes. We examined the relationship between maternal fluoride exposure, fertility, and birth outcomes in a Canadian pregnancy cohort living in areas where municipal drinking water fluoride concentrations ranged from 0.04 to 0.87 mg/L. METHODS: Using data from the Maternal-Infant Research on Environmental Chemicals (MIREC) study, we estimated fluoride exposure during pregnancy using three different metrics: (1) maternal urinary fluoride concentrations standardized for specific gravity (MUF(SG)) and averaged across all three trimesters (N = 1566), (2) water fluoride concentration (N = 1370), and (3) fluoride intake based on self-reported consumption of water, coffee, and tea, adjusted for body weight (N = 1192). Data on fertility, birth weight, gestational age, preterm birth, and small-for-gestational age (SGA) were assessed. We used multiple linear regression to examine associations between fluoride exposure, birth weight and gestational age, and logistic regression to examine associations with fertility, preterm birth, and SGA, adjusted for relevant covariates. RESULTS: Median (IQR) MUF(SG) was 0.50 (0.33–0.76) mg/L, median water fluoride was 0.52 (0.17–0.64) mg/L, and median fluoride intake was 0.008 (0.003–0.013) mg/kg/day. MUF(SG), water fluoride concentrations, and fluoride intake were not significantly associated with fertility, birth weight, gestational age, preterm birth, or SGA. Fetal sex did not modify any of the associations. CONCLUSION: Fluoride exposure during pregnancy was not associated with fertility or birth outcomes in this Canadian cohort. 2022-04 2021-11-02 /pmc/articles/PMC9837859/ /pubmed/36644332 http://dx.doi.org/10.1016/j.envadv.2021.100135 Text en https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/ (https://creativecommons.org/licenses/by-nc-nd/4.0/) ). |
spellingShingle | Article Goodman, Carly Hall, Meaghan Green, Rivka Hornung, Richard Martinez-Mier, Esperanza Angeles Lanphear, Bruce Till, Christine Maternal fluoride exposure, fertility and birth outcomes: The MIREC cohort |
title | Maternal fluoride exposure, fertility and birth outcomes: The MIREC cohort |
title_full | Maternal fluoride exposure, fertility and birth outcomes: The MIREC cohort |
title_fullStr | Maternal fluoride exposure, fertility and birth outcomes: The MIREC cohort |
title_full_unstemmed | Maternal fluoride exposure, fertility and birth outcomes: The MIREC cohort |
title_short | Maternal fluoride exposure, fertility and birth outcomes: The MIREC cohort |
title_sort | maternal fluoride exposure, fertility and birth outcomes: the mirec cohort |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837859/ https://www.ncbi.nlm.nih.gov/pubmed/36644332 http://dx.doi.org/10.1016/j.envadv.2021.100135 |
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