B cells expressing IgM B cell receptors of HIV-1 neutralizing antibodies discriminate antigen affinities by sensing binding association rates

HIV-1 envelope (Env) proteins designed to induce neutralizing antibody responses allow study of the role of affinities (equilibrium dissociation constant [K(D)]) and kinetic rates (association/dissociation rates) on B cell antigen recognition. It is unclear whether affinity discrimination during B c...

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Detalles Bibliográficos
Autores principales: Hossain, Md. Alamgir, Anasti, Kara, Watts, Brian, Cronin, Kenneth, Derking, Ronald, Groschel, Bettina, Kane, Advaiti Pai, Edwards, R.J., Easterhoff, David, Zhang, Jinsong, Rountree, Wes, Ortiz, Yaneth, Saunders, Kevin, Schief, William R., Sanders, Rogier W., Verkoczy, Laurent, Reth, Michael, Alam, S. Munir
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837990/
https://www.ncbi.nlm.nih.gov/pubmed/35767950
http://dx.doi.org/10.1016/j.celrep.2022.111021

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9837990/
https://www.ncbi.nlm.nih.gov/pubmed/35767950
http://dx.doi.org/10.1016/j.celrep.2022.111021

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