Systematic optimization of Cas12a base editors in wheat and maize using the ITER platform

BACKGROUND: Testing an ever-increasing number of CRISPR components is challenging when developing new genome engineering tools. Plant biotechnology has few high-throughput options to perform iterative design-build-test-learn cycles of gene-editing reagents. To bridge this gap, we develop ITER (Itera...

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Detalles Bibliográficos
Autores principales: Gaillochet, Christophe, Peña Fernández, Alexandra, Goossens, Vera, D’Halluin, Katelijn, Drozdzecki, Andrzej, Shafie, Myriam, Van Duyse, Julie, Van Isterdael, Gert, Gonzalez, Camila, Vermeersch, Mattias, De Saeger, Jonas, Develtere, Ward, Audenaert, Dominique, De Vleesschauwer, David, Meulewaeter, Frank, Jacobs, Thomas B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838060/
https://www.ncbi.nlm.nih.gov/pubmed/36639800
http://dx.doi.org/10.1186/s13059-022-02836-2

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