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Oxygenation index in the first three weeks of life is a predictor of bronchopulmonary dysplasia grade in very preterm infants

BACKGROUND: The new bronchopulmonary dysplasia (BPD) grading system was developed based on its correlation with long-term respiratory and neurodevelopmental outcomes and may provide better personalized prognostication. Identifying early-life predictors for accurate BPD grade prediction may allow int...

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Autores principales: Chou, Fu-Sheng, Leigh, Rebekah M., Rao, Srinandini S., Narang, Arvind, Yeh, Hung-Wen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838074/
https://www.ncbi.nlm.nih.gov/pubmed/36639768
http://dx.doi.org/10.1186/s12887-023-03835-3
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author Chou, Fu-Sheng
Leigh, Rebekah M.
Rao, Srinandini S.
Narang, Arvind
Yeh, Hung-Wen
author_facet Chou, Fu-Sheng
Leigh, Rebekah M.
Rao, Srinandini S.
Narang, Arvind
Yeh, Hung-Wen
author_sort Chou, Fu-Sheng
collection PubMed
description BACKGROUND: The new bronchopulmonary dysplasia (BPD) grading system was developed based on its correlation with long-term respiratory and neurodevelopmental outcomes and may provide better personalized prognostication. Identifying early-life predictors for accurate BPD grade prediction may allow interventions to be tailored to individual needs. This study aimed to assess whether oxygenation index (OI) dynamics in the first three weeks of life are a predictor of BPD grade. METHODS: A single-center retrospective study was performed. Generalized additive mixed modeling was used to model OI trajectories for each BPD grade subgroup. A multinomial regression model was then developed to quantify the association between OI dynamics and BPD grade. RESULTS: Two hundred fifty-four infants were identified for inclusion in the trajectory modeling. A total of 6,243 OI data points were available for modeling. OI trajectory estimates showed distinct patterns in the three groups, most prominent during the third week of life. The average daily OI change was -0.33 ± 0.52 (n = 85) in the No-BPD group, -0.04 ± 0.75 (n = 82) in the Low-Grade BPD group, and 0.22 ± 0.65 (n = 75) in the High-Grade BPD group (p < 0.001). A multinomial regression analysis showed the initial OI value and the average daily OI change both independently correlated with BPD grade outcomes after adjusting for birth gestation, birth weight z-score, sex, and the duration of invasive ventilation. CONCLUSION: Early-life OI dynamics may be a useful independent marker for BPD grade prediction. Prospective studies may be warranted to further validate the findings. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-023-03835-3.
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spelling pubmed-98380742023-01-14 Oxygenation index in the first three weeks of life is a predictor of bronchopulmonary dysplasia grade in very preterm infants Chou, Fu-Sheng Leigh, Rebekah M. Rao, Srinandini S. Narang, Arvind Yeh, Hung-Wen BMC Pediatr Research BACKGROUND: The new bronchopulmonary dysplasia (BPD) grading system was developed based on its correlation with long-term respiratory and neurodevelopmental outcomes and may provide better personalized prognostication. Identifying early-life predictors for accurate BPD grade prediction may allow interventions to be tailored to individual needs. This study aimed to assess whether oxygenation index (OI) dynamics in the first three weeks of life are a predictor of BPD grade. METHODS: A single-center retrospective study was performed. Generalized additive mixed modeling was used to model OI trajectories for each BPD grade subgroup. A multinomial regression model was then developed to quantify the association between OI dynamics and BPD grade. RESULTS: Two hundred fifty-four infants were identified for inclusion in the trajectory modeling. A total of 6,243 OI data points were available for modeling. OI trajectory estimates showed distinct patterns in the three groups, most prominent during the third week of life. The average daily OI change was -0.33 ± 0.52 (n = 85) in the No-BPD group, -0.04 ± 0.75 (n = 82) in the Low-Grade BPD group, and 0.22 ± 0.65 (n = 75) in the High-Grade BPD group (p < 0.001). A multinomial regression analysis showed the initial OI value and the average daily OI change both independently correlated with BPD grade outcomes after adjusting for birth gestation, birth weight z-score, sex, and the duration of invasive ventilation. CONCLUSION: Early-life OI dynamics may be a useful independent marker for BPD grade prediction. Prospective studies may be warranted to further validate the findings. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12887-023-03835-3. BioMed Central 2023-01-13 /pmc/articles/PMC9838074/ /pubmed/36639768 http://dx.doi.org/10.1186/s12887-023-03835-3 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Chou, Fu-Sheng
Leigh, Rebekah M.
Rao, Srinandini S.
Narang, Arvind
Yeh, Hung-Wen
Oxygenation index in the first three weeks of life is a predictor of bronchopulmonary dysplasia grade in very preterm infants
title Oxygenation index in the first three weeks of life is a predictor of bronchopulmonary dysplasia grade in very preterm infants
title_full Oxygenation index in the first three weeks of life is a predictor of bronchopulmonary dysplasia grade in very preterm infants
title_fullStr Oxygenation index in the first three weeks of life is a predictor of bronchopulmonary dysplasia grade in very preterm infants
title_full_unstemmed Oxygenation index in the first three weeks of life is a predictor of bronchopulmonary dysplasia grade in very preterm infants
title_short Oxygenation index in the first three weeks of life is a predictor of bronchopulmonary dysplasia grade in very preterm infants
title_sort oxygenation index in the first three weeks of life is a predictor of bronchopulmonary dysplasia grade in very preterm infants
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838074/
https://www.ncbi.nlm.nih.gov/pubmed/36639768
http://dx.doi.org/10.1186/s12887-023-03835-3
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