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Outcomes of Filipinos with inflammatory rheumatic diseases developing COVID-19 prior to vaccinations and new variants: a historical perspective

We described the profile and outcome of Filipino patients with inflammatory rheumatic diseases (IRDs) who developed COVID-19 (IRD-C19) during the onset of the pandemic, prior to vaccinations and variants. We obtained de-identified data of Filipino patients with IRD-C19 from the Global Rheumatology A...

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Autores principales: Zamora-Abrahan, Geraldine Tong, Salido, Evelyn Osio, Lichauco, Juan Javier Tayengco, Gutierrez-Rubio, Anna Kristina Manahan, Rivera-Go, Ivy Catherine Talavera, Cortez, Karen Joy Castañeda, Suilan, Katrina Elys Arada, Villo, Jimmy Gene Bobot, Del Rosario, Adora Gatlabayan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838254/
https://www.ncbi.nlm.nih.gov/pubmed/36637634
http://dx.doi.org/10.1007/s10067-023-06507-w
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author Zamora-Abrahan, Geraldine Tong
Salido, Evelyn Osio
Lichauco, Juan Javier Tayengco
Gutierrez-Rubio, Anna Kristina Manahan
Rivera-Go, Ivy Catherine Talavera
Cortez, Karen Joy Castañeda
Suilan, Katrina Elys Arada
Villo, Jimmy Gene Bobot
Del Rosario, Adora Gatlabayan
author_facet Zamora-Abrahan, Geraldine Tong
Salido, Evelyn Osio
Lichauco, Juan Javier Tayengco
Gutierrez-Rubio, Anna Kristina Manahan
Rivera-Go, Ivy Catherine Talavera
Cortez, Karen Joy Castañeda
Suilan, Katrina Elys Arada
Villo, Jimmy Gene Bobot
Del Rosario, Adora Gatlabayan
author_sort Zamora-Abrahan, Geraldine Tong
collection PubMed
description We described the profile and outcome of Filipino patients with inflammatory rheumatic diseases (IRDs) who developed COVID-19 (IRD-C19) during the onset of the pandemic, prior to vaccinations and variants. We obtained de-identified data of Filipino patients with IRD-C19 from the Global Rheumatology Alliance registry from March 2020 to August 2021. Descriptive statistics and multivariate analyses were applied. Registered were 164 patients (mean age 44 years; 70% female). The most common IRDs were systemic lupus erythematosus (SLE, 41.4%), rheumatoid arthritis (RA, 15.2%), and gout (14.6%). Majority were receiving conventional DMARDs (59.1%) and/or glucocorticoid therapy (GC, 51.2%). Half (58.5%) were hospitalized, with risk higher in active IRD (OR 3.7), heart disease (8.52), and hypertension (8.73); and lower in SLE patients (0.15). Among hospitalized patients, 76% needed supplemental oxygen. Heart disease (6.28), hypertension (7.6), and moderate-to-high IRD activity (3.37) were associated with higher odds of requiring oxygen supplementation. Hypertension was associated with mechanical ventilation (8.23). Twenty-four (15%) patients died, with odds lower if on prednisone ≥ 10 mg/day (0.17) and with other autoimmune IRDs aside from SLE and RA (0.05). Among patients with IRD-C19 prior to vaccinations and variants, higher disease activity, hypertension, and heart disease were associated with poorer outcomes. Prednisone ≥ 10 mg/day was associated with lower odds of death. This study provides valuable historical information, emphasizing the need for continued data collection to clarify COVID-19’s impact.
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spelling pubmed-98382542023-01-17 Outcomes of Filipinos with inflammatory rheumatic diseases developing COVID-19 prior to vaccinations and new variants: a historical perspective Zamora-Abrahan, Geraldine Tong Salido, Evelyn Osio Lichauco, Juan Javier Tayengco Gutierrez-Rubio, Anna Kristina Manahan Rivera-Go, Ivy Catherine Talavera Cortez, Karen Joy Castañeda Suilan, Katrina Elys Arada Villo, Jimmy Gene Bobot Del Rosario, Adora Gatlabayan Clin Rheumatol Brief Report We described the profile and outcome of Filipino patients with inflammatory rheumatic diseases (IRDs) who developed COVID-19 (IRD-C19) during the onset of the pandemic, prior to vaccinations and variants. We obtained de-identified data of Filipino patients with IRD-C19 from the Global Rheumatology Alliance registry from March 2020 to August 2021. Descriptive statistics and multivariate analyses were applied. Registered were 164 patients (mean age 44 years; 70% female). The most common IRDs were systemic lupus erythematosus (SLE, 41.4%), rheumatoid arthritis (RA, 15.2%), and gout (14.6%). Majority were receiving conventional DMARDs (59.1%) and/or glucocorticoid therapy (GC, 51.2%). Half (58.5%) were hospitalized, with risk higher in active IRD (OR 3.7), heart disease (8.52), and hypertension (8.73); and lower in SLE patients (0.15). Among hospitalized patients, 76% needed supplemental oxygen. Heart disease (6.28), hypertension (7.6), and moderate-to-high IRD activity (3.37) were associated with higher odds of requiring oxygen supplementation. Hypertension was associated with mechanical ventilation (8.23). Twenty-four (15%) patients died, with odds lower if on prednisone ≥ 10 mg/day (0.17) and with other autoimmune IRDs aside from SLE and RA (0.05). Among patients with IRD-C19 prior to vaccinations and variants, higher disease activity, hypertension, and heart disease were associated with poorer outcomes. Prednisone ≥ 10 mg/day was associated with lower odds of death. This study provides valuable historical information, emphasizing the need for continued data collection to clarify COVID-19’s impact. Springer International Publishing 2023-01-13 2023 /pmc/articles/PMC9838254/ /pubmed/36637634 http://dx.doi.org/10.1007/s10067-023-06507-w Text en © The Author(s), under exclusive licence to International League of Associations for Rheumatology (ILAR) 2023 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic.
spellingShingle Brief Report
Zamora-Abrahan, Geraldine Tong
Salido, Evelyn Osio
Lichauco, Juan Javier Tayengco
Gutierrez-Rubio, Anna Kristina Manahan
Rivera-Go, Ivy Catherine Talavera
Cortez, Karen Joy Castañeda
Suilan, Katrina Elys Arada
Villo, Jimmy Gene Bobot
Del Rosario, Adora Gatlabayan
Outcomes of Filipinos with inflammatory rheumatic diseases developing COVID-19 prior to vaccinations and new variants: a historical perspective
title Outcomes of Filipinos with inflammatory rheumatic diseases developing COVID-19 prior to vaccinations and new variants: a historical perspective
title_full Outcomes of Filipinos with inflammatory rheumatic diseases developing COVID-19 prior to vaccinations and new variants: a historical perspective
title_fullStr Outcomes of Filipinos with inflammatory rheumatic diseases developing COVID-19 prior to vaccinations and new variants: a historical perspective
title_full_unstemmed Outcomes of Filipinos with inflammatory rheumatic diseases developing COVID-19 prior to vaccinations and new variants: a historical perspective
title_short Outcomes of Filipinos with inflammatory rheumatic diseases developing COVID-19 prior to vaccinations and new variants: a historical perspective
title_sort outcomes of filipinos with inflammatory rheumatic diseases developing covid-19 prior to vaccinations and new variants: a historical perspective
topic Brief Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838254/
https://www.ncbi.nlm.nih.gov/pubmed/36637634
http://dx.doi.org/10.1007/s10067-023-06507-w
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