The neoepitope of the complement C5b-9 Membrane Attack Complex is formed by proximity of adjacent ancillary regions of C9

The Membrane Attack Complex (MAC) is responsible for forming large β-barrel channels in the membranes of pathogens, such as gram-negative bacteria. Off-target MAC assembly on endogenous tissue is associated with inflammatory diseases and cancer. Accordingly, a human C5b-9 specific antibody, aE11, ha...

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Detalles Bibliográficos
Autores principales: Bayly-Jones, Charles, Ho, Bill H. T., Lau, Corinna, Leung, Eleanor W. W., D’Andrea, Laura, Lupton, Christopher J., Ekkel, Susan M., Venugopal, Hariprasad, Whisstock, James C., Mollnes, Tom E., Spicer, Bradley A., Dunstone, Michelle A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838529/
https://www.ncbi.nlm.nih.gov/pubmed/36639734
http://dx.doi.org/10.1038/s42003-023-04431-y

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