Cargando…

Aquaporin5 Deficiency Aggravates ROS/NLRP3 Inflammasome-Mediated Pyroptosis in the Lacrimal Glands

PURPOSE: The pathogenesis of the lacrimal glands (LGs) is facilitated by inflammation mediated by the NACHT, LRR, and NLRP3 inflammasomes in dry eye disease. This research aimed to explore the protective effects of Aquaporin 5 (AQP5) on LGs by inhibiting reactive oxygen species (ROS) and the NLRP3 i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Cao, Xin, Di, Guohu, Bai, Ying, Zhang, Kaier, Wang, Yihui, Zhao, Hui, Wang, Dianqiang, Chen, Peng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The Association for Research in Vision and Ophthalmology 2023
Materias:	Biochemistry and Molecular Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838588/ https://www.ncbi.nlm.nih.gov/pubmed/36626177 http://dx.doi.org/10.1167/iovs.64.1.4

Ejemplares similares

Lacrimal gland homeostasis is maintained by the AQP5 pathway by attenuating endoplasmic reticulum stress inflammation in the lacrimal gland of AQP5 knockout mice
por: Hu, Shaohua, et al.
Publicado: (2021)

Regulation of Axon Guidance by Slit2 and Netrin-1 Signaling in the Lacrimal Gland of Aqp5 Knockout Mice
por: Bai, Ying, et al.
Publicado: (2023)

NLRP3 inflammasome activation mediates sleep deprivation-induced pyroptosis in mice
por: Fan, Kun, et al.
Publicado: (2021)

Human Lacrimal Gland Derived Mesenchymal Stem Cells – Isolation, Propagation, and Characterization
por: Jaffet, Jilu, et al.
Publicado: (2023)

Novel Insights Into Muscarinic and Purinergic Responses in Primary Cultures of Rat Lacrimal Gland Myoepithelial Cells
por: Dankis, Martin, et al.
Publicado: (2021)

Lacrimal Gland Denervation Alters Tear Protein Composition and Impairs Ipsilateral Eye Closures and Corneal Nociception
por: Hegarty, Deborah M., et al.
Publicado: (2018)

Role of FGF10/FGFR2b Signaling in Homeostasis and Regeneration of Adult Lacrimal Gland and Corneal Epithelium Proliferation
por: Finburgh, Emma N., et al.
Publicado: (2023)

Hyperglycemia Aggravates Periodontitis via Autophagy Impairment and ROS-Inflammasome-Mediated Macrophage Pyroptosis
por: Zhao, Zhenxing, et al.
Publicado: (2023)

Microcystin-LR Induces and Aggravates Colitis through NLRP3 Inflammasome-Mediated Pyroptosis in Mice
por: Yang, Yue, et al.
Publicado: (2023)

Fine particulate matter exposure aggravates ischemic injury via NLRP3 inflammasome activation and pyroptosis
por: Gao, Li, et al.
Publicado: (2022)

Breviscapine alleviates podocyte injury by inhibiting NF-κB/NLRP3-mediated pyroptosis in diabetic nephropathy
por: Sun, Linlin, et al.
Publicado: (2023)

NLRP3 Inflammasome Activation-Mediated Pyroptosis Aggravates Myocardial Ischemia/Reperfusion Injury in Diabetic Rats
por: Qiu, Zhen, et al.
Publicado: (2017)

Corilagin Restrains NLRP3 Inflammasome Activation and Pyroptosis through the ROS/TXNIP/NLRP3 Pathway to Prevent Inflammation
por: Luo, Tianyu, et al.
Publicado: (2022)

Theacrine alleviates sepsis-induced acute kidney injury by repressing the activation of NLRP3/Caspase-1 inflammasome
por: Yang, Maoxian, et al.
Publicado: (2022)

Aquaporin 5 maintains lens transparency by regulating the lysosomal pathway using circRNA
por: Shaohua, Hu, et al.
Publicado: (2023)

Pyroptosis in NLRP3 inflammasome-related atherosclerosis
por: Zeng, Xiang, et al.
Publicado: (2022)

Changes of the ocular surface and aquaporins in the lacrimal glands of rabbits during pregnancy
por: Ding, Chuanqing, et al.
Publicado: (2011)

PSMB5 Alleviates Ulcerative Colitis by Inhibiting ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis
por: Han, Liang, et al.
Publicado: (2022)

NLRP3 inflammasome-induced pyroptosis in digestive system tumors
por: Wen, Jiexia, et al.
Publicado: (2023)

Aquaporins 8 and 9 as Possible Markers for Adult Murine Lacrimal Gland Cells
por: Okada, Naoko, et al.
Publicado: (2021)

Retracted: PSMB5 Alleviates Ulcerative Colitis by Inhibiting ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis
por: Markers, Disease
Publicado: (2023)

Resveratrol improves cardiac function and left ventricular fibrosis after myocardial infarction in rats by inhibiting NLRP3 inflammasome activity and the TGF-β1/SMAD2 signaling pathway
por: Jiang, Jinjin, et al.
Publicado: (2021)

Lipopolysaccharide (LPS) Aggravates High Glucose- and Hypoxia/Reoxygenation-Induced Injury through Activating ROS-Dependent NLRP3 Inflammasome-Mediated Pyroptosis in H9C2 Cardiomyocytes
por: Qiu, Zhen, et al.
Publicado: (2019)

Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice
por: Wang, Renqing, et al.
Publicado: (2017)

Loganin Attenuates High Glucose-Induced Schwann Cells Pyroptosis by Inhibiting ROS Generation and NLRP3 Inflammasome Activation
por: Cheng, Yu-Chi, et al.
Publicado: (2020)

Emerging Role of NLRP3 Inflammasome/Pyroptosis in Huntington’s Disease
por: Paldino, Emanuela, et al.
Publicado: (2022)

Emerging Role of NLRP3 Inflammasome and Pyroptosis in Liver Transplantation
por: Lucas-Ruiz, Fernando, et al.
Publicado: (2022)

TIGAR deficiency induces caspase-1-dependent trophoblasts pyroptosis through NLRP3-ASC inflammasome
por: Guo, Junjun, et al.
Publicado: (2023)

Lacrimal Gland Microenvironment Changes After Obstruction of Lacrimal Gland Ducts
por: He, Xin, et al.
Publicado: (2022)

Aerobic exercise alleviates pyroptosis-related diseases by regulating NLRP3 inflammasome
por: Hu, Shujuan, et al.
Publicado: (2022)

Viral Glycoproteins Induce NLRP3 Inflammasome Activation and Pyroptosis in Macrophages
por: Eisfeld, Hannah S., et al.
Publicado: (2021)

The NLRP1 Inflammasome Induces Pyroptosis in Human Corneal Epithelial Cells
por: Griswold, Andrew R., et al.
Publicado: (2022)

The mechanisms of NLRP3 inflammasome/pyroptosis activation and their role in diabetic retinopathy
por: Zheng, Xiaoqin, et al.
Publicado: (2023)

Salidroside Ameliorates Alzheimer's Disease by Targeting NLRP3 Inflammasome-Mediated Pyroptosis
por: Cai, Yawen, et al.
Publicado: (2022)

High Glucose Aggravates Retinal Endothelial Cell Dysfunction by Activating the RhoA/ROCK1/pMLC/Connexin43 Signaling Pathway
por: Zhao, Hongran, et al.
Publicado: (2022)

Reprogramming Macrophage Metabolism and its Effect on NLRP3 Inflammasome Activation in Sepsis
por: Luo, Ruiheng, et al.
Publicado: (2022)

HHcy Induces Pyroptosis and Atherosclerosis via the Lipid Raft-Mediated NOX-ROS-NLRP3 Inflammasome Pathway in apoE(−/−) Mice
por: Liu, Sijun, et al.
Publicado: (2022)

Paeonol regulates NLRP3 inflammasomes and pyroptosis to alleviate spinal cord injury of rat
por: Zhao, Houling, et al.
Publicado: (2022)

Notch Signaling in Meibomian Gland Epithelial Cell Differentiation
por: Gidfar, Sanaz, et al.
Publicado: (2016)

Myeloid Nrf2 deficiency aggravates non-alcoholic steatohepatitis progression by regulating YAP-mediated NLRP3 inflammasome signaling
por: Wang, Peng, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_g6ca9risr571evv8n6c749dg60