Leveraging edge-centric networks complements existing network-level inference for functional connectomes

The human connectome is modular with distinct brain regions clustering together to form large-scale communities, or networks. This concept has recently been leveraged in novel inferencing procedures by averaging the edge-level statistics within networks to induce more powerful inferencing at the network level. However, these networks are constructed based on the similarity between pairs of nodes. Emerging work has described novel edge-centric networks, which instead use the similarity between pairs of edges to construct networks. In this work, we use these edge-centric networks in a network-level inferencing procedure and compare this novel method to traditional inferential procedures and the network-level procedure using node-centric networks. We use data from the Human Connectome Project, the Healthy Brain Network, and the Philadelphia Neurodevelopmental Cohort and use a resampling technique with various sample sizes (n=40, 80, 120) to probe the power and specificity of each method. Across datasets and sample sizes, using the edge-centric networks outperforms using node-centric networks for inference as well as edge-level FDR correction and NBS. Additionally, the edge-centric networks were found to be more consistent in clustering effect sizes of similar values as compared to node-centric networks, although node-centric networks often had a lower average within-network effect size variability. Together, these findings suggest that using edge-centric networks for network-level inference can procure relatively powerful results while remaining similarly accurate to the underlying edge-level effects across networks, complementing previous inferential methods.