Efficient computation of adjoint sensitivities at steady-state in ODE models of biochemical reaction networks

Dynamical models in the form of systems of ordinary differential equations have become a standard tool in systems biology. Many parameters of such models are usually unknown and have to be inferred from experimental data. Gradient-based optimization has proven to be effective for parameter estimatio...

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Detalles Bibliográficos
Autores principales: Lakrisenko, Polina, Stapor, Paul, Grein, Stephan, Paszkowski, Łukasz, Pathirana, Dilan, Fröhlich, Fabian, Lines, Glenn Terje, Weindl, Daniel, Hasenauer, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838866/
https://www.ncbi.nlm.nih.gov/pubmed/36595539
http://dx.doi.org/10.1371/journal.pcbi.1010783

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838866/
https://www.ncbi.nlm.nih.gov/pubmed/36595539
http://dx.doi.org/10.1371/journal.pcbi.1010783

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