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Efficient computation of adjoint sensitivities at steady-state in ODE models of biochemical reaction networks
Dynamical models in the form of systems of ordinary differential equations have become a standard tool in systems biology. Many parameters of such models are usually unknown and have to be inferred from experimental data. Gradient-based optimization has proven to be effective for parameter estimatio...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9838866/ https://www.ncbi.nlm.nih.gov/pubmed/36595539 http://dx.doi.org/10.1371/journal.pcbi.1010783 |