Relationship between years since menopause and lipid variation in postmenopausal women: A cross-sectional study

Lipid alteration in postmenopausal women is commonly due to hormonal changes. This study aimed to explore the association between the years since menopause and lipid profiles in postmenopausal women. In this cross-sectional study, a total of 1033 postmenopausal women were recruited from the Women’s...

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Autores principales: Lou, Zheng, Huang, Yizhou, Lan, Yibing, Li, Chunming, Chu, Ketan, Chen, Peiqiong, Xu, Wenxian, Ma, Linjuan, Zhou, Jianhong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839288/
https://www.ncbi.nlm.nih.gov/pubmed/36637918
http://dx.doi.org/10.1097/MD.0000000000032684
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author Lou, Zheng
Huang, Yizhou
Lan, Yibing
Li, Chunming
Chu, Ketan
Chen, Peiqiong
Xu, Wenxian
Ma, Linjuan
Zhou, Jianhong
author_facet Lou, Zheng
Huang, Yizhou
Lan, Yibing
Li, Chunming
Chu, Ketan
Chen, Peiqiong
Xu, Wenxian
Ma, Linjuan
Zhou, Jianhong
author_sort Lou, Zheng
collection PubMed
description Lipid alteration in postmenopausal women is commonly due to hormonal changes. This study aimed to explore the association between the years since menopause and lipid profiles in postmenopausal women. In this cross-sectional study, a total of 1033 postmenopausal women were recruited from the Women’s Hospital of Zhejiang University in China between 2015 and 2022. Each participant was interviewed using questionnaires regarding sociodemographic and reproductive data. Anthropometric measurements, lipid profiles, and reproductive hormone levels were assessed. Participants were divided into 3 groups based on the length of time since menopause: 2, 2 to 5.9, and 6 years. Differences in lipid profiles and reproductive hormones among the groups were compared. Logistic and linear regression analyses were used to examine the relationship between years after menopause and lipid profile. High-density lipoprotein cholesterol (HDL-C) and luteinizing hormone levels were significantly lower in postmenopausal women with time since menopause of ≥6 years than those <2 years (P < .05), whereas low-density lipoprotein cholesterol levels were significantly higher (P < .05). A longer time after menopause was independently associated with lower HDL-C levels (β, −0.059, standard error, 0.023, P = .01) after adjustment for age, body mass index, and other confounders. Compared to women who had menopause for <2 years, those who were postmenopausal for >6 years had lower HDL-C levels after adjustment for age, body mass index, and other covariates (β, −0.123, 95% confidence interval, [−0.221, −0.014], P = .014). Longer time since menopause was associated with an atherogenic lipid profile with appreciably low levels of HDL-C subfraction. Future multicenter studies are necessary to examine postmenopausal population and determine how differences in lipids influence the risk of cardiovascular disease in this group.
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spelling pubmed-98392882023-01-17 Relationship between years since menopause and lipid variation in postmenopausal women: A cross-sectional study Lou, Zheng Huang, Yizhou Lan, Yibing Li, Chunming Chu, Ketan Chen, Peiqiong Xu, Wenxian Ma, Linjuan Zhou, Jianhong Medicine (Baltimore) 5600 Lipid alteration in postmenopausal women is commonly due to hormonal changes. This study aimed to explore the association between the years since menopause and lipid profiles in postmenopausal women. In this cross-sectional study, a total of 1033 postmenopausal women were recruited from the Women’s Hospital of Zhejiang University in China between 2015 and 2022. Each participant was interviewed using questionnaires regarding sociodemographic and reproductive data. Anthropometric measurements, lipid profiles, and reproductive hormone levels were assessed. Participants were divided into 3 groups based on the length of time since menopause: 2, 2 to 5.9, and 6 years. Differences in lipid profiles and reproductive hormones among the groups were compared. Logistic and linear regression analyses were used to examine the relationship between years after menopause and lipid profile. High-density lipoprotein cholesterol (HDL-C) and luteinizing hormone levels were significantly lower in postmenopausal women with time since menopause of ≥6 years than those <2 years (P < .05), whereas low-density lipoprotein cholesterol levels were significantly higher (P < .05). A longer time after menopause was independently associated with lower HDL-C levels (β, −0.059, standard error, 0.023, P = .01) after adjustment for age, body mass index, and other confounders. Compared to women who had menopause for <2 years, those who were postmenopausal for >6 years had lower HDL-C levels after adjustment for age, body mass index, and other covariates (β, −0.123, 95% confidence interval, [−0.221, −0.014], P = .014). Longer time since menopause was associated with an atherogenic lipid profile with appreciably low levels of HDL-C subfraction. Future multicenter studies are necessary to examine postmenopausal population and determine how differences in lipids influence the risk of cardiovascular disease in this group. Lippincott Williams & Wilkins 2023-01-13 /pmc/articles/PMC9839288/ /pubmed/36637918 http://dx.doi.org/10.1097/MD.0000000000032684 Text en Copyright © 2023 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial License 4.0 (CCBY-NC) (https://creativecommons.org/licenses/by-nc/4.0/) , where it is permissible to download, share, remix, transform, and buildup the work provided it is properly cited. The work cannot be used commercially without permission from the journal.
spellingShingle 5600
Lou, Zheng
Huang, Yizhou
Lan, Yibing
Li, Chunming
Chu, Ketan
Chen, Peiqiong
Xu, Wenxian
Ma, Linjuan
Zhou, Jianhong
Relationship between years since menopause and lipid variation in postmenopausal women: A cross-sectional study
title Relationship between years since menopause and lipid variation in postmenopausal women: A cross-sectional study
title_full Relationship between years since menopause and lipid variation in postmenopausal women: A cross-sectional study
title_fullStr Relationship between years since menopause and lipid variation in postmenopausal women: A cross-sectional study
title_full_unstemmed Relationship between years since menopause and lipid variation in postmenopausal women: A cross-sectional study
title_short Relationship between years since menopause and lipid variation in postmenopausal women: A cross-sectional study
title_sort relationship between years since menopause and lipid variation in postmenopausal women: a cross-sectional study
topic 5600
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839288/
https://www.ncbi.nlm.nih.gov/pubmed/36637918
http://dx.doi.org/10.1097/MD.0000000000032684
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