Cargando…

Escape from NK cell tumor surveillance by NGFR-induced lipid remodeling in melanoma

Metastatic disease is a major cause of death for patients with melanoma. Melanoma cells can become metastatic not only due to cell-intrinsic plasticity but also due to cancer-induced protumorigenic remodeling of the immune microenvironment. Here, we report that innate immune surveillance by natural...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lehmann, Julia, Caduff, Nicole, Krzywińska, Ewelina, Stierli, Salome, Salas-Bastos, Adrian, Loos, Benjamin, Levesque, Mitchell P., Dummer, Reinhard, Stockmann, Christian, Münz, Christian, Diener, Johanna, Sommer, Lukas
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Association for the Advancement of Science 2023
Materias:	Biomedicine and Life Sciences
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839334/ https://www.ncbi.nlm.nih.gov/pubmed/36638181 http://dx.doi.org/10.1126/sciadv.adc8825

Ejemplares similares

Rapid test to assess the escape of SARS-CoV-2 variants of concern
por: Heggestad, Jacob T., et al.
Publicado: (2021)

Extracellular matrix proteins regulate NK cell function in peripheral tissues
por: Bunting, Mark D., et al.
Publicado: (2022)

When killers become thieves: Trogocytosed PD-1 inhibits NK cells in cancer
por: Hasim, Mohamed S., et al.
Publicado: (2022)

High-salt diet mediates interplay between NK cells and gut microbiota to induce potent tumor immunity
por: Rizvi, Zaigham Abbas, et al.
Publicado: (2021)

Na, K-ATPase α1 cooperates with its endogenous ligand to reprogram immune microenvironment of lung carcinoma and promotes immune escape
por: Yang, Kaiyong, et al.
Publicado: (2023)

POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape from innate immune sensing
por: Thenin-Houssier, Suzie, et al.
Publicado: (2023)

Loss of metabolic fitness drives tumor resistance after CAR-NK cell therapy and can be overcome by cytokine engineering
por: Li, Li, et al.
Publicado: (2023)

High-throughput and high-content bioassay enables tuning of polyester nanoparticles for cellular uptake, endosomal escape, and systemic in vivo delivery of mRNA
por: Rui, Yuan, et al.
Publicado: (2022)

Single-cycle influenza virus vaccine generates lung CD8(+) Trm that cross-react against viral variants and subvert virus escape mutants
por: Zheng, Ming Z. M., et al.
Publicado: (2023)

High-resolution profiling of MHC II peptide presentation capacity reveals SARS-CoV-2 CD4 T cell targets and mechanisms of immune escape
por: Obermair, Franz-Josef, et al.
Publicado: (2022)

Hypoxia, Metabolism and Immune Cell Function
por: Krzywinska, Ewelina, et al.
Publicado: (2018)

Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity against ovarian cancers
por: Bordoloi, Devivasha, et al.
Publicado: (2023)

CHEK2 signaling is the key regulator of oocyte survival after chemotherapy
por: Emori, Chihiro, et al.
Publicado: (2023)

The ER protein Creld regulates ER-mitochondria contact dynamics and respiratory complex 1 activity
por: Paradis, Marie, et al.
Publicado: (2022)

An AMPK phosphoregulated RhoGEF feedback loop tunes cortical flow–driven amoeboid migration in vivo
por: Lin, Benjamin, et al.
Publicado: (2022)

Regulation of 3′ splice site selection after step 1 of splicing by spliceosomal C* proteins
por: Dybkov, Olexandr, et al.
Publicado: (2023)

COP1 dynamics integrate conflicting seasonal light and thermal cues in the control of Arabidopsis elongation
por: Nieto, Cristina, et al.
Publicado: (2022)

Cell-autonomous diversification in bacteria arises from calcium dynamics self-organizing at a critical point
por: Meyer, Christian T., et al.
Publicado: (2023)

Germline immortality relies on TRIM32-mediated turnover of a maternal mRNA activator in C. elegans
por: Oyewale, Tosin D., et al.
Publicado: (2022)

Structural snapshots of human PepT1 and PepT2 reveal mechanistic insights into substrate and drug transport across epithelial membranes
por: Killer, Maxime, et al.
Publicado: (2021)

NK cells in hypoxic skin mediate a trade-off between wound healing and antibacterial defence
por: Sobecki, Michal, et al.
Publicado: (2021)

Brain inflammation triggers macrophage invasion across the blood-brain barrier in Drosophila during pupal stages
por: Winkler, Bente, et al.
Publicado: (2021)

Rhomboid-catalyzed intramembrane proteolysis requires hydrophobic matching with the surrounding lipid bilayer
por: Engberg, Oskar, et al.
Publicado: (2022)

The energetics and ion coupling of cholesterol transport through Patched1
por: Ansell, T. Bertie, et al.
Publicado: (2023)

Constitutive Turbodomains enhance expansion and antitumor activity of allogeneic BCMA CAR T cells in preclinical models
por: Lin, Regina J., et al.
Publicado: (2023)

Progressive alterations in amino acid and lipid metabolism correlate with peripheral neuropathy in Polg(D257A) mice
por: Lim, Esther W., et al.
Publicado: (2021)

Diurnal metabolic control in cyanobacteria requires perception of second messenger signaling molecule c-di-AMP by the carbon control protein SbtB
por: Selim, Khaled A., et al.
Publicado: (2021)

Nanotoxoid vaccination protects against opportunistic bacterial infections arising from immunodeficiency
por: Zhou, Jiarong, et al.
Publicado: (2022)

Epistasis between promoter activity and coding mutations shapes gene evolvability
por: Cisneros, Angel F., et al.
Publicado: (2023)

A conditional Smg6 mutant mouse model reveals circadian clock regulation through the nonsense-mediated mRNA decay pathway
por: Katsioudi, Georgia, et al.
Publicado: (2023)

SUMO-activated target traps (SATTs) enable the identification of a comprehensive E3-specific SUMO proteome
por: Salas-Lloret, Daniel, et al.
Publicado: (2023)

Invasive Staphylococcus epidermidis uses a unique processive wall teichoic acid glycosyltransferase to evade immune recognition
por: Guo, Yinglan, et al.
Publicado: (2023)

Targeted gene silencing in the nervous system with CRISPR-Cas13
por: Powell, Jackson E., et al.
Publicado: (2022)

Mitigation of Pseudomonas syringae virulence by signal inactivation
por: Sieber, Simon, et al.
Publicado: (2021)

Exposure of volunteers to microgravity by dry immersion bed over 21 days results in gene expression changes and adaptation of T cells
por: Gallardo-Dodd, Carlos J., et al.
Publicado: (2023)

Tox2 is required for the maintenance of GC T(FH) cells and the generation of memory T(FH) cells
por: Horiuchi, Shu, et al.
Publicado: (2021)

Essential role of Cp190 in physical and regulatory boundary formation
por: Kaushal, Anjali, et al.
Publicado: (2022)

Endothelial versus pronephron fate decision is modulated by the transcription factors Cloche/Npas4l, Tal1, and Lmo2
por: Mattonet, Kenny, et al.
Publicado: (2022)

Inter-organelle cross-talk supports acetyl-coenzyme A homeostasis and lipogenesis under metabolic stress
por: Kuna, Ramya S., et al.
Publicado: (2023)

Multi-tiered approach to detect autoimmune cross-reactivity of therapeutic T cell receptors
por: Ishii, Kazusa, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_0taqpt8qig5nq3utoqbrnld8os