T cell-derived interleukin-22 drives the expression of CD155 by cancer cells to suppress NK cell function and promote metastasis

Although T cells can exert potent anti-tumor immunity, a subset of T helper (Th) cells producing interleukin-22 (IL-22) in breast and lung tumors is linked to dismal patient outcome. Here, we examined the mechanisms whereby these T cells contribute to disease. In murine models of lung and breast can...

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Detalles Bibliográficos
Autores principales: Briukhovetska, Daria, Suarez-Gosalvez, Javier, Voigt, Cornelia, Markota, Anamarija, Giannou, Anastasios D., Schübel, Maryam, Jobst, Jakob, Zhang, Tao, Dörr, Janina, Märkl, Florian, Majed, Lina, Müller, Philipp Jie, May, Peter, Gottschlich, Adrian, Tokarew, Nicholas, Lücke, Jöran, Oner, Arman, Schwerdtfeger, Melanie, Andreu-Sanz, David, Grünmeier, Ruth, Seifert, Matthias, Michaelides, Stefanos, Hristov, Michael, König, Lars M., Cadilha, Bruno Loureiro, Mikhaylov, Oleg, Anders, Hans-Joachim, Rothenfusser, Simon, Flavell, Richard A., Cerezo-Wallis, Daniela, Tejedo, Cristina, Soengas, María S., Bald, Tobias, Huber, Samuel, Endres, Stefan, Kobold, Sebastian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839367/
https://www.ncbi.nlm.nih.gov/pubmed/36630913
http://dx.doi.org/10.1016/j.immuni.2022.12.010

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