Pembrolizumab Induced Calcitriol-Mediated Hypercalcemia

PD-1/PD-L1 inhibitors such as pembrolizumab have radically improved the prognosis for many patients with advanced malignancies. Although revolutionary, its use can be complicated and limited by various immune-related adverse effects. Effective management depends on early recognition and prompt inter...

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Detalles Bibliográficos
Autores principales: Oommen, Tiffany T., Sun, Kelly, Barranco-Trabi, Javier, Berenberg, Jeffrey, Kim, Myungjin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839403/
https://www.ncbi.nlm.nih.gov/pubmed/36644340
http://dx.doi.org/10.1155/2023/9160326
Descripción
Sumario:PD-1/PD-L1 inhibitors such as pembrolizumab have radically improved the prognosis for many patients with advanced malignancies. Although revolutionary, its use can be complicated and limited by various immune-related adverse effects. Effective management depends on early recognition and prompt intervention. Herein, we describe a unique syndrome of hypercalcemia, with associated acute renal injury and hypoxic respiratory failure that was responsive to corticosteroids suggestive of immunotoxicity from pembrolizumab.

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