A GP130-Targeting Small Molecule, LMT-28, Reduces LPS-Induced Bone Resorption around Implants in Diabetic Models by Inhibiting IL-6/GP130/JAK2/STAT3 Signaling

In this study, we examined the effect of the GP130-targeting molecule, LMT-28, on lipopolysaccharide- (LPS-) induced bone resorption around implants in diabetic models using in vitro and rat animal experiments. First, LMT-28 was added to osteoblasts stimulated by LPS and advanced glycation end produ...

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Detalles Bibliográficos
Autores principales: Liu, Qi-qi, Wu, Wei-wei, Yang, Jian, Wang, Rui-bin, Yuan, Ling-ling, Peng, Pei-zhao, Zeng, Mao-yun, Yu, Ke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839413/
https://www.ncbi.nlm.nih.gov/pubmed/36643585
http://dx.doi.org/10.1155/2023/9330439

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