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Influence of maternal and perinatal factors on macronutrient content of very preterm human milk during the first weeks after birth
OBJECTIVE: To identify changes in macronutrient content of very preterm human milk associated with perinatal factors. STUDY DESIGN: Milk macronutrients were measured on weeks 1, 2, 4 and 8 with mid-infrared transmission spectrometers. RESULT: We assessed 625 samples (from 117 mothers and 130 very pr...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Nature Publishing Group US
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839448/ https://www.ncbi.nlm.nih.gov/pubmed/35931800 http://dx.doi.org/10.1038/s41372-022-01475-6 |
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author | Borràs-Novell, Cristina Herranz Barbero, Ana Balcells Esponera, Carla López-Abad, Miriam Aldecoa Bilbao, Victoria Izquierdo Renau, Montserrat Iglesias Platas, Isabel |
author_facet | Borràs-Novell, Cristina Herranz Barbero, Ana Balcells Esponera, Carla López-Abad, Miriam Aldecoa Bilbao, Victoria Izquierdo Renau, Montserrat Iglesias Platas, Isabel |
author_sort | Borràs-Novell, Cristina |
collection | PubMed |
description | OBJECTIVE: To identify changes in macronutrient content of very preterm human milk associated with perinatal factors. STUDY DESIGN: Milk macronutrients were measured on weeks 1, 2, 4 and 8 with mid-infrared transmission spectrometers. RESULT: We assessed 625 samples (from 117 mothers and 130 very preterm infants). Average concentrations were: protein 1.3 ± 0.3 g/dl, carbohydrates 7.3 ± 0.6 g/dl, fat 3.7 ± 1.0 g/dl and energy 296.0 ± 41.0 kJ/dl (70.7 kcal/dl). Gestational age negatively correlated with protein (rho: −0.307, p < 0.001) and energy (r: −0.193, p = 0.003). Advanced maternal age, gestational age and intrauterine growth restriction were independently associated with milk protein content over the first 4 weeks (adjusted R(2): 0.113, p = 0.002). CONCLUSION: These findings may help neonatologists identify patients fed Mother´s Own Milk who are at increased risk of poor postnatal growth. |
format | Online Article Text |
id | pubmed-9839448 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Nature Publishing Group US |
record_format | MEDLINE/PubMed |
spelling | pubmed-98394482023-01-15 Influence of maternal and perinatal factors on macronutrient content of very preterm human milk during the first weeks after birth Borràs-Novell, Cristina Herranz Barbero, Ana Balcells Esponera, Carla López-Abad, Miriam Aldecoa Bilbao, Victoria Izquierdo Renau, Montserrat Iglesias Platas, Isabel J Perinatol Article OBJECTIVE: To identify changes in macronutrient content of very preterm human milk associated with perinatal factors. STUDY DESIGN: Milk macronutrients were measured on weeks 1, 2, 4 and 8 with mid-infrared transmission spectrometers. RESULT: We assessed 625 samples (from 117 mothers and 130 very preterm infants). Average concentrations were: protein 1.3 ± 0.3 g/dl, carbohydrates 7.3 ± 0.6 g/dl, fat 3.7 ± 1.0 g/dl and energy 296.0 ± 41.0 kJ/dl (70.7 kcal/dl). Gestational age negatively correlated with protein (rho: −0.307, p < 0.001) and energy (r: −0.193, p = 0.003). Advanced maternal age, gestational age and intrauterine growth restriction were independently associated with milk protein content over the first 4 weeks (adjusted R(2): 0.113, p = 0.002). CONCLUSION: These findings may help neonatologists identify patients fed Mother´s Own Milk who are at increased risk of poor postnatal growth. Nature Publishing Group US 2022-08-05 2023 /pmc/articles/PMC9839448/ /pubmed/35931800 http://dx.doi.org/10.1038/s41372-022-01475-6 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . |
spellingShingle | Article Borràs-Novell, Cristina Herranz Barbero, Ana Balcells Esponera, Carla López-Abad, Miriam Aldecoa Bilbao, Victoria Izquierdo Renau, Montserrat Iglesias Platas, Isabel Influence of maternal and perinatal factors on macronutrient content of very preterm human milk during the first weeks after birth |
title | Influence of maternal and perinatal factors on macronutrient content of very preterm human milk during the first weeks after birth |
title_full | Influence of maternal and perinatal factors on macronutrient content of very preterm human milk during the first weeks after birth |
title_fullStr | Influence of maternal and perinatal factors on macronutrient content of very preterm human milk during the first weeks after birth |
title_full_unstemmed | Influence of maternal and perinatal factors on macronutrient content of very preterm human milk during the first weeks after birth |
title_short | Influence of maternal and perinatal factors on macronutrient content of very preterm human milk during the first weeks after birth |
title_sort | influence of maternal and perinatal factors on macronutrient content of very preterm human milk during the first weeks after birth |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839448/ https://www.ncbi.nlm.nih.gov/pubmed/35931800 http://dx.doi.org/10.1038/s41372-022-01475-6 |
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