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Theta tACS impairs episodic memory more than tDCS

Episodic memory deficits are a common consequence of aging and are associated with a number of neurodegenerative disorders (e.g., Alzheimer’s disease). Given the importance of episodic memory, a great deal of research has investigated how we can improve memory performance. Transcranial electrical st...

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Autores principales: Murray, Nicholas W. G., Graham, Petra L., Sowman, Paul F., Savage, Greg
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839727/
https://www.ncbi.nlm.nih.gov/pubmed/36639676
http://dx.doi.org/10.1038/s41598-022-27190-y
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author Murray, Nicholas W. G.
Graham, Petra L.
Sowman, Paul F.
Savage, Greg
author_facet Murray, Nicholas W. G.
Graham, Petra L.
Sowman, Paul F.
Savage, Greg
author_sort Murray, Nicholas W. G.
collection PubMed
description Episodic memory deficits are a common consequence of aging and are associated with a number of neurodegenerative disorders (e.g., Alzheimer’s disease). Given the importance of episodic memory, a great deal of research has investigated how we can improve memory performance. Transcranial electrical stimulation (TES) represents a promising tool for memory enhancement but the optimal stimulation parameters that reliably boost memory are yet to be determined. In our double-blind, randomised, sham-controlled study, 42 healthy adults (36 females; 23.3 ± 7.7 years of age) received anodal transcranial direct current stimulation (tDCS), theta transcranial alternating current stimulation (tACS) and sham stimulation during a list-learning task, over three separate sessions. Stimulation was applied over the left temporal lobe, as encoding and recall of information is typically associated with mesial temporal lobe structures (e.g., the hippocampus and entorhinal cortex). We measured word recall within each stimulation session, as well as the average number of intrusion and repetition errors. In terms of word recall, participants recalled fewer words during tDCS and tACS, compared to sham stimulation, and significantly fewer words recalled during tACS compared with tDCS. Significantly more memory errors were also made during tACS compared with sham stimulation. Overall, our findings suggest that TES has a deleterious effect on memory processes when applied to the left temporal lobe.
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spelling pubmed-98397272023-01-15 Theta tACS impairs episodic memory more than tDCS Murray, Nicholas W. G. Graham, Petra L. Sowman, Paul F. Savage, Greg Sci Rep Article Episodic memory deficits are a common consequence of aging and are associated with a number of neurodegenerative disorders (e.g., Alzheimer’s disease). Given the importance of episodic memory, a great deal of research has investigated how we can improve memory performance. Transcranial electrical stimulation (TES) represents a promising tool for memory enhancement but the optimal stimulation parameters that reliably boost memory are yet to be determined. In our double-blind, randomised, sham-controlled study, 42 healthy adults (36 females; 23.3 ± 7.7 years of age) received anodal transcranial direct current stimulation (tDCS), theta transcranial alternating current stimulation (tACS) and sham stimulation during a list-learning task, over three separate sessions. Stimulation was applied over the left temporal lobe, as encoding and recall of information is typically associated with mesial temporal lobe structures (e.g., the hippocampus and entorhinal cortex). We measured word recall within each stimulation session, as well as the average number of intrusion and repetition errors. In terms of word recall, participants recalled fewer words during tDCS and tACS, compared to sham stimulation, and significantly fewer words recalled during tACS compared with tDCS. Significantly more memory errors were also made during tACS compared with sham stimulation. Overall, our findings suggest that TES has a deleterious effect on memory processes when applied to the left temporal lobe. Nature Publishing Group UK 2023-01-13 /pmc/articles/PMC9839727/ /pubmed/36639676 http://dx.doi.org/10.1038/s41598-022-27190-y Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Murray, Nicholas W. G.
Graham, Petra L.
Sowman, Paul F.
Savage, Greg
Theta tACS impairs episodic memory more than tDCS
title Theta tACS impairs episodic memory more than tDCS
title_full Theta tACS impairs episodic memory more than tDCS
title_fullStr Theta tACS impairs episodic memory more than tDCS
title_full_unstemmed Theta tACS impairs episodic memory more than tDCS
title_short Theta tACS impairs episodic memory more than tDCS
title_sort theta tacs impairs episodic memory more than tdcs
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839727/
https://www.ncbi.nlm.nih.gov/pubmed/36639676
http://dx.doi.org/10.1038/s41598-022-27190-y
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