Formaldehyde reacts with N-terminal proline residues to give bicyclic aminals

Formaldehyde (HCHO) is a potent electrophile that is toxic above threshold levels, but which is also produced in the nuclei of eukaryotic cells by demethylases. We report studies with the four canonical human histones revealing that histone H2B reacts with HCHO, including as generated by a histone d...

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Detalles Bibliográficos
Autores principales: John, Tobias, Pires, Elisabete, Hester, Svenja S., Salah, Eidarus, Hopkinson, Richard J., Schofield, Christopher J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839752/
https://www.ncbi.nlm.nih.gov/pubmed/36698022
http://dx.doi.org/10.1038/s42004-022-00801-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839752/
https://www.ncbi.nlm.nih.gov/pubmed/36698022
http://dx.doi.org/10.1038/s42004-022-00801-5

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