PPDPF Promotes the Development of Mutant KRAS‐Driven Pancreatic Ductal Adenocarcinoma by Regulating the GEF Activity of SOS1

The guanine nucleotide exchange factor (GEF) SOS1 catalyzes the exchange of GDP for GTP on RAS. However, regulation of the GEF activity remains elusive. Here, the authors report that PPDPF functions as an important regulator of SOS1. The expression of PPDPF is significantly increased in pancreatic d...

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Detalles Bibliográficos
Autores principales: Ni, Qian‐Zhi, Zhu, Bing, Ji, Yan, Zheng, Qian‐Wen, Liang, Xin, Ma, Ning, Jiang, Hao, Zhang, Feng‐Kun, Shang, Yu‐Rong, Wang, Yi‐Kang, Xu, Sheng, Zhang, Er‐Bin, Yuan, Yan‐Mei, Chen, Tian‐Wei, Yin, Fen‐Fen, Cao, Hui‐Jun, Huang, Jing‐Yi, Xia, Ji, Ding, Xu‐Fen, Qiu, Xiao‐Song, Ding, Kai, Song, Chao, Zhou, Wen‐Tao, Wu, Meng, Wang, Kang, Lui, Rui, Lin, Qiu, Chen, Wei, Li, Zhi‐Gang, Cheng, Shu‐Qun, Wang, Xiao‐Fan, Xie, Dong, Li, Jing‐Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9839844/
https://www.ncbi.nlm.nih.gov/pubmed/36453576
http://dx.doi.org/10.1002/advs.202202448

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