Comparative evaluation of biased agonists Sarcosine(1), d‐Alanine (8) ‐Angiotensin (Ang) II (SD Ang II) and Sarcosine(1), Isoleucine (8) ‐Ang II (SI Ang II) and their radioiodinated congeners binding to rat liver membrane AT(1) receptors

Angiotensin II analogue and β‐arrestin biased agonist TRV027 (Sarcosine(1), d‐Alanine(8)‐Angiotensin (Ang) II; SD Ang II), developed by Trevena, Inc. in the early 2010s, brought hopes of a novel treatment for cardiovascular diseases, due to its ability to simultaneously cause signaling through the β...

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Detalles Bibliográficos
Autores principales: Noto, Natalia M., Restrepo, Yazmin M., Pang, Hong W., Stoyell‐Conti, Filipe, West, Crystal A., Speth, Robert C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2023
Materias:
Original Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840060/
https://www.ncbi.nlm.nih.gov/pubmed/36639940
http://dx.doi.org/10.1002/prp2.1053

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