Abnormal morphology and function in retinal ganglion cells derived from patients-specific iPSCs generated from individuals with Leber’s hereditary optic neuropathy

Leber’s hereditary optic neuropathy (LHON) is a maternally inherited eye disease that results from degeneration of retinal ganglion cells (RGC). Mitochondrial ND4 11778G > A mutation, which affects structural components of complex I, is the most prevalent LHON-associated mitochondrial DNA (mtDNA)...

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Detalles Bibliográficos
Autores principales: Nie, Zhipeng, Wang, Chenghui, Chen, Jiarong, Ji, Yanchun, Zhang, Hongxing, Zhao, Fuxin, Zhou, Xiangtian, Guan, Min-Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840204/
https://www.ncbi.nlm.nih.gov/pubmed/35947995
http://dx.doi.org/10.1093/hmg/ddac190

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