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Vitamin C boosts DNA demethylation in TET2 germline mutation carriers

BACKGROUND: Accurate regulation of DNA methylation is necessary for normal cells to differentiate, develop and function. TET2 catalyzes stepwise DNA demethylation in hematopoietic cells. Mutations in the TET2 gene predispose to hematological malignancies by causing DNA methylation overload and aberr...

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Detalles Bibliográficos
Autores principales:	Taira, Aurora, Palin, Kimmo, Kuosmanen, Anna, Välimäki, Niko, Kuittinen, Outi, Kuismin, Outi, Kaasinen, Eevi, Rajamäki, Kristiina, Aaltonen, Lauri A.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840351/ https://www.ncbi.nlm.nih.gov/pubmed/36639817 http://dx.doi.org/10.1186/s13148-022-01404-6

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