Low-Dose Methotrexate Toxicity Presenting as Pancytopenia

High-dose methotrexate (MTX, 5 g/week) is typically used for the treatment of different malignancies and may be associated with serious side effects, such as acute kidney injury, myelosuppression, and hepatotoxicity. On the other hand, low-dose MTX (10-25 mg/week) is considered to be a safe and effe...

Descripción completa

Detalles Bibliográficos
Autores principales: Dhillon, Gundip S, Chauhan, Sukhjinder, Jalal, Yema, Ghobrial, Youssef, Ahmed, Birjees
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2022
Materias:
Internal Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840410/
https://www.ncbi.nlm.nih.gov/pubmed/36654616
http://dx.doi.org/10.7759/cureus.32494
_version_ 1784869636870766592
author Dhillon, Gundip S
Chauhan, Sukhjinder
Jalal, Yema
Ghobrial, Youssef
Ahmed, Birjees
author_facet Dhillon, Gundip S
Chauhan, Sukhjinder
Jalal, Yema
Ghobrial, Youssef
Ahmed, Birjees
author_sort Dhillon, Gundip S
collection PubMed
description High-dose methotrexate (MTX, 5 g/week) is typically used for the treatment of different malignancies and may be associated with serious side effects, such as acute kidney injury, myelosuppression, and hepatotoxicity. On the other hand, low-dose MTX (10-25 mg/week) is considered to be a safe and effective treatment for autoimmune arthropathies. Toxicity due to low-dose MTX is rare but can present with serious complications, such as pancytopenia. In this report, we present the case of an 82-year-old woman who presented with low-dose, MTX-induced severe pancytopenia and was treated with leucovorin rescue therapy with granulocyte colony-stimulating factor (G-CSF) therapy.
format Online
Article
Text
id pubmed-9840410
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Cureus
record_format MEDLINE/PubMed
spelling pubmed-98404102023-01-17 Low-Dose Methotrexate Toxicity Presenting as Pancytopenia Dhillon, Gundip S Chauhan, Sukhjinder Jalal, Yema Ghobrial, Youssef Ahmed, Birjees Cureus Internal Medicine High-dose methotrexate (MTX, 5 g/week) is typically used for the treatment of different malignancies and may be associated with serious side effects, such as acute kidney injury, myelosuppression, and hepatotoxicity. On the other hand, low-dose MTX (10-25 mg/week) is considered to be a safe and effective treatment for autoimmune arthropathies. Toxicity due to low-dose MTX is rare but can present with serious complications, such as pancytopenia. In this report, we present the case of an 82-year-old woman who presented with low-dose, MTX-induced severe pancytopenia and was treated with leucovorin rescue therapy with granulocyte colony-stimulating factor (G-CSF) therapy. Cureus 2022-12-13 /pmc/articles/PMC9840410/ /pubmed/36654616 http://dx.doi.org/10.7759/cureus.32494 Text en Copyright © 2022, Dhillon et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Internal Medicine
Dhillon, Gundip S
Chauhan, Sukhjinder
Jalal, Yema
Ghobrial, Youssef
Ahmed, Birjees
Low-Dose Methotrexate Toxicity Presenting as Pancytopenia
title Low-Dose Methotrexate Toxicity Presenting as Pancytopenia
title_full Low-Dose Methotrexate Toxicity Presenting as Pancytopenia
title_fullStr Low-Dose Methotrexate Toxicity Presenting as Pancytopenia
title_full_unstemmed Low-Dose Methotrexate Toxicity Presenting as Pancytopenia
title_short Low-Dose Methotrexate Toxicity Presenting as Pancytopenia
title_sort low-dose methotrexate toxicity presenting as pancytopenia
topic Internal Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840410/
https://www.ncbi.nlm.nih.gov/pubmed/36654616
http://dx.doi.org/10.7759/cureus.32494
work_keys_str_mv AT dhillongundips lowdosemethotrexatetoxicitypresentingaspancytopenia
AT chauhansukhjinder lowdosemethotrexatetoxicitypresentingaspancytopenia
AT jalalyema lowdosemethotrexatetoxicitypresentingaspancytopenia
AT ghobrialyoussef lowdosemethotrexatetoxicitypresentingaspancytopenia
AT ahmedbirjees lowdosemethotrexatetoxicitypresentingaspancytopenia

Ejemplares similares