Integration of High-Throughput Imaging and Multiparametric Metabolic Profiling Reveals a Mitochondrial Mechanism of Tenofovir Toxicity

Nephrotoxicity is a major cause of kidney disease and failure in drug development, but understanding of cellular mechanisms is limited, highlighting the need for better experimental models and methodological approaches. Most nephrotoxins damage the proximal tubule (PT), causing functional impairment...

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Detalles Bibliográficos
Autores principales: Pearson, Adam, Haenni, Dominik, Bouitbir, Jamal, Hunt, Matthew, Payne, Brendan A I, Sachdeva, Ashwin, Hung, Rachel K Y, Post, Frank A, Connolly, John, Nlandu-Khodo, Stellor, Jankovic, Nevena, Bugarski, Milica, Hall, Andrew M
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840465/
https://www.ncbi.nlm.nih.gov/pubmed/36654930
http://dx.doi.org/10.1093/function/zqac065

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