Cargando…

Sulforaphane Delays Intervertebral Disc Degeneration by Alleviating Endoplasmic Reticulum Stress in Nucleus Pulposus Cells via Activating Nrf-2/HO-1

Intervertebral disc degeneration (IVDD) is one of the main causes of low back pain, which brings heavy burdens to individuals and society. The mechanism of IVDD is complex and diverse. One of the important reasons is that the abnormal accumulation of reactive oxygen species (ROS) in nucleus pulposus...

Descripción completa

Detalles Bibliográficos
Autores principales:	Lu, Xiao, Xu, Guangyu, Lin, Zhidi, Song, Jian, Zhang, Yuxuan, Wang, Hongli, Lu, Feizhou, Xia, Xinlei, Ma, Xiaosheng, Zou, Fei, Jiang, Jianyuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840554/ https://www.ncbi.nlm.nih.gov/pubmed/36647429 http://dx.doi.org/10.1155/2023/3626091

Ejemplares similares

Roles of circular RNAs in the pathogenesis of intervertebral disc degeneration (Review)
por: Lin, Zhidi, et al.
Publicado: (2021)

Carbohydrate sulfotransferase 3 (CHST3) overexpression promotes cartilage endplate‐derived stem cells (CESCs) to regulate molecular mechanisms related to repair of intervertebral disc degeneration by rat nucleus pulposus
por: Guan, Yunzhi, et al.
Publicado: (2021)

Dimethyl Fumarate Ameliorates Nucleus Pulposus Cell Dysfunction through Activating the Nrf2/HO-1 Pathway in Intervertebral Disc Degeneration
por: Wang, Ruihong, et al.
Publicado: (2021)

CircERCC2 ameliorated intervertebral disc degeneration by regulating mitophagy and apoptosis through miR-182-5p/SIRT1 axis
por: Xie, Lin, et al.
Publicado: (2019)

Progerin accumulation in nucleus pulposus cells impairs mitochondrial function and induces intervertebral disc degeneration and therapeutic effects of sulforaphane
por: Xu, Xiaolong, et al.
Publicado: (2019)

Endoplasmic reticulum stress associates with the development of intervertebral disc degeneration
por: Huang, Jishang, et al.
Publicado: (2023)

Eicosapentaenoic Acid-Induced Autophagy Attenuates Intervertebral Disc Degeneration by Suppressing Endoplasmic Reticulum Stress, Extracellular Matrix Degradation, and Apoptosis
por: Lin, Zhen, et al.
Publicado: (2021)

Endoplasmic Reticulum Stress: An Emerging Therapeutic Target for Intervertebral Disc Degeneration
por: Wang, Dong, et al.
Publicado: (2022)

Analysis of the correlative factors in the selection of interbody fusion cage height in transforaminal lumbar interbody fusion
por: Wang, Hongli, et al.
Publicado: (2016)

The Pathology of Type II Modic Changes: Fat Deposition or Osteosclerosis? A Study Using CT Scan
por: Sun, Chi, et al.
Publicado: (2018)

Senescence of Nucleus Pulposus Chondrocytes in Human Intervertebral Discs
por: Kim, Ki-Won, et al.
Publicado: (2008)

Proteomic Signature of Nucleus Pulposus in Fetal Intervertebral Disc
por: Rajasekaran, Shanmuganathan, et al.
Publicado: (2020)

Exosomes from mesenchymal stem cells modulate endoplasmic reticulum stress to protect against nucleus pulposus cell death and ameliorate intervertebral disc degeneration in vivo
por: Liao, Zhiwei, et al.
Publicado: (2019)

Effects of puerarin on the intervertebral disc degeneration and biological characteristics of nucleus pulposus cells
por: Tang, Hengtao, et al.
Publicado: (2022)

Tension induces intervertebral disc degeneration via endoplasmic reticulum stress-mediated autophagy
por: Chen, Jiangwei, et al.
Publicado: (2019)

Dihydroorotate dehydrogenase regulates ferroptosis in neurons after spinal cord injury via the P53‐ALOX15 signaling pathway
por: Li, Dachuan, et al.
Publicado: (2023)

Andrographolide Inhibits Static Mechanical Pressure-Induced Intervertebral Disc Degeneration via the MAPK/Nrf2/HO-1 Pathway
por: Zhang, Cunxin, et al.
Publicado: (2023)

Endoscopic removal of nucleus pulposus of intervertebral disc on lumbar intervertebral disc protrusion and the influence on inflammatory factors and immune function
por: Xu, Gang, et al.
Publicado: (2020)

Exhaustion of nucleus pulposus progenitor cells with ageing and degeneration of the intervertebral disc
por: Sakai, Daisuke, et al.
Publicado: (2012)

Changes in the Molecular Phenotype of Nucleus Pulposus Cells with Intervertebral Disc Aging
por: Tang, Xinyan, et al.
Publicado: (2012)

Characterisation of porous knitted titanium for replacement of intervertebral disc nucleus pulposus
por: Tendulkar, Gauri, et al.
Publicado: (2017)

Circular RNAs in nucleus pulposus cell function and intervertebral disc degeneration
por: Li, Zheng, et al.
Publicado: (2019)

Can a Nomogram Help to Predict the Overall and Cancer-specific Survival of Patients With Chondrosarcoma?
por: Song, Kehan, et al.
Publicado: (2018)

A study of screw placement to obtain the optimal pull-out resistance of lumbar pedicle screws—analysis of Hounsfield units measurements based on computed tomography
por: Li, Dachuan, et al.
Publicado: (2022)

Biomechanical effects of interbody cage height on adjacent segments in patients with lumbar degeneration: a 3D finite element study
por: Lu, Xiao, et al.
Publicado: (2022)

How to reconstruct the lordosis of cervical spine in patients with Hirayama disease? A finite element analysis of biomechanical changes focusing on adjacent segments after anterior cervical discectomy and fusion
por: Lu, Xiao, et al.
Publicado: (2022)

Interobserver and Intraobserver Reproducibility and Reliability of the Huashan Clinical Classification System for Hirayama Disease
por: Sun, Chi, et al.
Publicado: (2021)

Successful fishing for nucleus pulposus progenitor cells of the intervertebral disc across species
por: Sakai, Daisuke, et al.
Publicado: (2018)

Natural Products of Pharmacology and Mechanisms in Nucleus Pulposus Cells and Intervertebral Disc Degeneration
por: Chen, Hai-Wei, et al.
Publicado: (2021)

Expression of ANGPTL4 in Nucleus Pulposus Tissues Is Associated with Intervertebral Disc Degeneration
por: Liu, Fan-jie, et al.
Publicado: (2021)

GLUT1 is redundant in hypoxic and glycolytic nucleus pulposus cells of the intervertebral disc
por: Johnston, Shira N., et al.
Publicado: (2023)

Promoting Nrf2/Sirt3-Dependent Mitophagy Suppresses Apoptosis in Nucleus Pulposus Cells and Protects against Intervertebral Disc Degeneration
por: Hu, Sunli, et al.
Publicado: (2021)

Can preoperative cervical spinal diffusion tensor imaging (DTI) indices predict surgical outcomes in patients with Hirayama disease? A retrospective cohort study
por: Gao, Yuan, et al.
Publicado: (2022)

Sulforaphane Attenuates Contrast-Induced Nephropathy in Rats via Nrf2/HO-1 Pathway
por: Zhao, Zhihong, et al.
Publicado: (2016)

Engineered exosomes enriched in netrin-1 modRNA promote axonal growth in spinal cord injury by attenuating inflammation and pyroptosis
por: Lu, Xiao, et al.
Publicado: (2023)

p38 MAPK Facilitates Crosstalk Between Endoplasmic Reticulum Stress and IL-6 Release in the Intervertebral Disc
por: Krupkova, Olga, et al.
Publicado: (2018)

Stiffening of the nucleus pulposus upon axial loading of the intervertebral disc: An experimental in situ study
por: Beekmans, Steven V., et al.
Publicado: (2018)

Autologous fibroblasts induce fibrosis of the nucleus pulposus to maintain the stability of degenerative intervertebral discs
por: Chen, Chen, et al.
Publicado: (2020)

Injectable hydrogel with nucleus pulposus-matched viscoelastic property prevents intervertebral disc degeneration
por: Jia, Haoruo, et al.
Publicado: (2022)

Discovery and Application of Postnatal Nucleus Pulposus Progenitors Essential for Intervertebral Disc Homeostasis and Degeneration
por: Gao, Bo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_q8af28i05uh8eogheepa324uhn