Cargando…

Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis

OBJECTIVES: DCI and hydrocephalus are the most common complications that predict poor outcomes after aSAH. The relationship between sex, DCI and hydrocephalus are not well established; thus, we aimed to examine sex differences in DCI and hydrocephalus following aSAH in a systematic review and meta-a...

Descripción completa

Detalles Bibliográficos
Autores principales: Rehman, Sabah, Phan, Hoang T., Chandra, Ronil V., Gall, Seana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Vienna 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840585/
https://www.ncbi.nlm.nih.gov/pubmed/36333624
http://dx.doi.org/10.1007/s00701-022-05399-0
_version_ 1784869666393423872
author Rehman, Sabah
Phan, Hoang T.
Chandra, Ronil V.
Gall, Seana
author_facet Rehman, Sabah
Phan, Hoang T.
Chandra, Ronil V.
Gall, Seana
author_sort Rehman, Sabah
collection PubMed
description OBJECTIVES: DCI and hydrocephalus are the most common complications that predict poor outcomes after aSAH. The relationship between sex, DCI and hydrocephalus are not well established; thus, we aimed to examine sex differences in DCI and hydrocephalus following aSAH in a systematic review and meta-analysis. METHODS: A systematic search was conducted using the PubMed, Scopus and Medline databases from inception to August 2022 to identify cohort, case control, case series and clinical studies reporting sex and DCI, acute and chronic shunt-dependent hydrocephalus (SDHC). Random-effects meta-analysis was used to pool estimates for available studies. RESULTS: There were 56 studies with crude estimates for DCI and meta-analysis showed that women had a greater risk for DCI than men (OR 1.24, 95% CI 1.11–1.39). The meta-analysis for adjusted estimates for 9 studies also showed an association between sex and DCI (OR 1.61, 95% CI 1.27–2.05). For acute hydrocephalus, only 9 studies were included, and meta-analysis of unadjusted estimates showed no association with sex (OR 0.95, 95%CI 0.78–1.16). For SDHC, a meta-analysis of crude estimates from 53 studies showed that women had a somewhat greater risk of developing chronic hydrocephalus compared to men (OR 1.14, 95% CI 0.99–1.31). In meta-analysis for adjusted estimates from 5 studies, no association of sex with SDHC was observed (OR 0.87, 95% CI 0.57–1.33). CONCLUSIONS: Female sex is associated with the development of DCI; however, an association between sex and hydrocephalus was not detected. Strategies to target females to reduce the development of DCI may decrease overall morbidity and mortality after aSAH. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00701-022-05399-0.
format Online
Article
Text
id pubmed-9840585
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Springer Vienna
record_format MEDLINE/PubMed
spelling pubmed-98405852023-01-16 Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis Rehman, Sabah Phan, Hoang T. Chandra, Ronil V. Gall, Seana Acta Neurochir (Wien) Review Article - Vascular Neurosurgery - Aneurysm OBJECTIVES: DCI and hydrocephalus are the most common complications that predict poor outcomes after aSAH. The relationship between sex, DCI and hydrocephalus are not well established; thus, we aimed to examine sex differences in DCI and hydrocephalus following aSAH in a systematic review and meta-analysis. METHODS: A systematic search was conducted using the PubMed, Scopus and Medline databases from inception to August 2022 to identify cohort, case control, case series and clinical studies reporting sex and DCI, acute and chronic shunt-dependent hydrocephalus (SDHC). Random-effects meta-analysis was used to pool estimates for available studies. RESULTS: There were 56 studies with crude estimates for DCI and meta-analysis showed that women had a greater risk for DCI than men (OR 1.24, 95% CI 1.11–1.39). The meta-analysis for adjusted estimates for 9 studies also showed an association between sex and DCI (OR 1.61, 95% CI 1.27–2.05). For acute hydrocephalus, only 9 studies were included, and meta-analysis of unadjusted estimates showed no association with sex (OR 0.95, 95%CI 0.78–1.16). For SDHC, a meta-analysis of crude estimates from 53 studies showed that women had a somewhat greater risk of developing chronic hydrocephalus compared to men (OR 1.14, 95% CI 0.99–1.31). In meta-analysis for adjusted estimates from 5 studies, no association of sex with SDHC was observed (OR 0.87, 95% CI 0.57–1.33). CONCLUSIONS: Female sex is associated with the development of DCI; however, an association between sex and hydrocephalus was not detected. Strategies to target females to reduce the development of DCI may decrease overall morbidity and mortality after aSAH. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s00701-022-05399-0. Springer Vienna 2022-11-04 2023 /pmc/articles/PMC9840585/ /pubmed/36333624 http://dx.doi.org/10.1007/s00701-022-05399-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Review Article - Vascular Neurosurgery - Aneurysm
Rehman, Sabah
Phan, Hoang T.
Chandra, Ronil V.
Gall, Seana
Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis
title Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis
title_full Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis
title_fullStr Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis
title_full_unstemmed Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis
title_short Is sex a predictor for delayed cerebral ischaemia (DCI) and hydrocephalus after aneurysmal subarachnoid haemorrhage (aSAH)? A systematic review and meta-analysis
title_sort is sex a predictor for delayed cerebral ischaemia (dci) and hydrocephalus after aneurysmal subarachnoid haemorrhage (asah)? a systematic review and meta-analysis
topic Review Article - Vascular Neurosurgery - Aneurysm
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840585/
https://www.ncbi.nlm.nih.gov/pubmed/36333624
http://dx.doi.org/10.1007/s00701-022-05399-0
work_keys_str_mv AT rehmansabah issexapredictorfordelayedcerebralischaemiadciandhydrocephalusafteraneurysmalsubarachnoidhaemorrhageasahasystematicreviewandmetaanalysis
AT phanhoangt issexapredictorfordelayedcerebralischaemiadciandhydrocephalusafteraneurysmalsubarachnoidhaemorrhageasahasystematicreviewandmetaanalysis
AT chandraronilv issexapredictorfordelayedcerebralischaemiadciandhydrocephalusafteraneurysmalsubarachnoidhaemorrhageasahasystematicreviewandmetaanalysis
AT gallseana issexapredictorfordelayedcerebralischaemiadciandhydrocephalusafteraneurysmalsubarachnoidhaemorrhageasahasystematicreviewandmetaanalysis