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Effect of date molasses on levetiracetam pharmacokinetics in healthy rats

Twelve healthy eight-week-old male Wistar rats weighing 200 g were used. Rats were chosen randomly, and their tails were identified and separated into cages/groups. The first group received an oral dose of 11.5 mg of levetiracetam in 5 mL of water, and the second group was given date syrup (250 g mi...

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Autores principales: Abu Dayyih, Wael, Layth, Raghad, Hailat, Mohammad, Alkhawaja, Bayan, Al Tamimi, Lina, Zakaraya, Zainab, Aburumman, Aseel, Al Dmour, Nisreen, Saadh, Mohamed J., Al-Matubsi, Hisham, Aldalaen, Saed M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840612/
https://www.ncbi.nlm.nih.gov/pubmed/36641484
http://dx.doi.org/10.1038/s41598-023-28074-5
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author Abu Dayyih, Wael
Layth, Raghad
Hailat, Mohammad
Alkhawaja, Bayan
Al Tamimi, Lina
Zakaraya, Zainab
Aburumman, Aseel
Al Dmour, Nisreen
Saadh, Mohamed J.
Al-Matubsi, Hisham
Aldalaen, Saed M.
author_facet Abu Dayyih, Wael
Layth, Raghad
Hailat, Mohammad
Alkhawaja, Bayan
Al Tamimi, Lina
Zakaraya, Zainab
Aburumman, Aseel
Al Dmour, Nisreen
Saadh, Mohamed J.
Al-Matubsi, Hisham
Aldalaen, Saed M.
author_sort Abu Dayyih, Wael
collection PubMed
description Twelve healthy eight-week-old male Wistar rats weighing 200 g were used. Rats were chosen randomly, and their tails were identified and separated into cages/groups. The first group received an oral dose of 11.5 mg of levetiracetam in 5 mL of water, and the second group was given date syrup (250 g mixed with 250 mL water) for seven days, then 11.5 mg LEV in 5 mL water on day 7. One week of preadministered date molasses significantly decreased levetiracetam pharmacokinetic parameters in rats, such as C(max) (72 vs. 14 ng/mL, p = 0.01), T(max) (1.78 vs. 0.44 h, p < 0.001), and AUC (880 vs. 258 ng.h/mL, p < 0.001). This decrease in plasma levetiracetam levels caused by date molasses could be attributed to decreased levetiracetam absorption. On the other hand, the current study discovered that rats given date molasses for a week had a reduced rate and extent of absorption. As a result, date molasses might increase the risk of epileptic seizures in oral LEV-treated ones.
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spelling pubmed-98406122023-01-16 Effect of date molasses on levetiracetam pharmacokinetics in healthy rats Abu Dayyih, Wael Layth, Raghad Hailat, Mohammad Alkhawaja, Bayan Al Tamimi, Lina Zakaraya, Zainab Aburumman, Aseel Al Dmour, Nisreen Saadh, Mohamed J. Al-Matubsi, Hisham Aldalaen, Saed M. Sci Rep Article Twelve healthy eight-week-old male Wistar rats weighing 200 g were used. Rats were chosen randomly, and their tails were identified and separated into cages/groups. The first group received an oral dose of 11.5 mg of levetiracetam in 5 mL of water, and the second group was given date syrup (250 g mixed with 250 mL water) for seven days, then 11.5 mg LEV in 5 mL water on day 7. One week of preadministered date molasses significantly decreased levetiracetam pharmacokinetic parameters in rats, such as C(max) (72 vs. 14 ng/mL, p = 0.01), T(max) (1.78 vs. 0.44 h, p < 0.001), and AUC (880 vs. 258 ng.h/mL, p < 0.001). This decrease in plasma levetiracetam levels caused by date molasses could be attributed to decreased levetiracetam absorption. On the other hand, the current study discovered that rats given date molasses for a week had a reduced rate and extent of absorption. As a result, date molasses might increase the risk of epileptic seizures in oral LEV-treated ones. Nature Publishing Group UK 2023-01-14 /pmc/articles/PMC9840612/ /pubmed/36641484 http://dx.doi.org/10.1038/s41598-023-28074-5 Text en © The Author(s) 2023 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Abu Dayyih, Wael
Layth, Raghad
Hailat, Mohammad
Alkhawaja, Bayan
Al Tamimi, Lina
Zakaraya, Zainab
Aburumman, Aseel
Al Dmour, Nisreen
Saadh, Mohamed J.
Al-Matubsi, Hisham
Aldalaen, Saed M.
Effect of date molasses on levetiracetam pharmacokinetics in healthy rats
title Effect of date molasses on levetiracetam pharmacokinetics in healthy rats
title_full Effect of date molasses on levetiracetam pharmacokinetics in healthy rats
title_fullStr Effect of date molasses on levetiracetam pharmacokinetics in healthy rats
title_full_unstemmed Effect of date molasses on levetiracetam pharmacokinetics in healthy rats
title_short Effect of date molasses on levetiracetam pharmacokinetics in healthy rats
title_sort effect of date molasses on levetiracetam pharmacokinetics in healthy rats
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840612/
https://www.ncbi.nlm.nih.gov/pubmed/36641484
http://dx.doi.org/10.1038/s41598-023-28074-5
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