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The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia

OBJECTIVE: Portulaca oleracea, commonly known as Purslane, is traditionally used as a sour, diuretic, and cooling herb with hemostatic properties. The present study evaluates the antianemic effect of methanolic and aqueous extracts of P. oleracea in a phenylhydrazine model of anemia. MATERIALS AND M...

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Autores principales: Shirani, Kobra, Riahi-Zanjani, Bamdad, Omidkhoda, Seyed Navid, Barangi, Samira, Karimi, Gholamreza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Mashhad University of Medical Sciences 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840774/
https://www.ncbi.nlm.nih.gov/pubmed/36698739
http://dx.doi.org/10.22038/AJP.2022.20965
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author Shirani, Kobra
Riahi-Zanjani, Bamdad
Omidkhoda, Seyed Navid
Barangi, Samira
Karimi, Gholamreza
author_facet Shirani, Kobra
Riahi-Zanjani, Bamdad
Omidkhoda, Seyed Navid
Barangi, Samira
Karimi, Gholamreza
author_sort Shirani, Kobra
collection PubMed
description OBJECTIVE: Portulaca oleracea, commonly known as Purslane, is traditionally used as a sour, diuretic, and cooling herb with hemostatic properties. The present study evaluates the antianemic effect of methanolic and aqueous extracts of P. oleracea in a phenylhydrazine model of anemia. MATERIALS AND METHODS: Phenylhydrazine (60 mg/kg/day, i.p., two consecutive days) was used to induce anemia in rats. The aqueous and methanolic extracts of P. oleracea were prepared, and three methods of treatment were defined with two doses (500 and 750 mg/kg, i.p.). The hematological parameters and blood cell morphology, total and direct bilirubin, and morphology, and pathology of bone marrow were evaluated. RESULTS: The results showed that the methanolic extract has better effects than aqueous extract in improving phenylhydrazine-induced anemia. Our results showed that administration of 500 and 750 mg/kg of P. oleracea methanolic extracts for 4 days could protect against the development of anemia caused by phenylhydrazine. CONCLUSION: In summary, the methanolic extracts of P. oleracea might be effective in phenylhydrazine-induced anemia.
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spelling pubmed-98407742023-01-24 The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia Shirani, Kobra Riahi-Zanjani, Bamdad Omidkhoda, Seyed Navid Barangi, Samira Karimi, Gholamreza Avicenna J Phytomed Original Research Article OBJECTIVE: Portulaca oleracea, commonly known as Purslane, is traditionally used as a sour, diuretic, and cooling herb with hemostatic properties. The present study evaluates the antianemic effect of methanolic and aqueous extracts of P. oleracea in a phenylhydrazine model of anemia. MATERIALS AND METHODS: Phenylhydrazine (60 mg/kg/day, i.p., two consecutive days) was used to induce anemia in rats. The aqueous and methanolic extracts of P. oleracea were prepared, and three methods of treatment were defined with two doses (500 and 750 mg/kg, i.p.). The hematological parameters and blood cell morphology, total and direct bilirubin, and morphology, and pathology of bone marrow were evaluated. RESULTS: The results showed that the methanolic extract has better effects than aqueous extract in improving phenylhydrazine-induced anemia. Our results showed that administration of 500 and 750 mg/kg of P. oleracea methanolic extracts for 4 days could protect against the development of anemia caused by phenylhydrazine. CONCLUSION: In summary, the methanolic extracts of P. oleracea might be effective in phenylhydrazine-induced anemia. Mashhad University of Medical Sciences 2023 /pmc/articles/PMC9840774/ /pubmed/36698739 http://dx.doi.org/10.22038/AJP.2022.20965 Text en https://creativecommons.org/licenses/by/3.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License, (http://creativecommons.org/licenses/by/3.0/ (https://creativecommons.org/licenses/by/3.0/) ) which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research Article
Shirani, Kobra
Riahi-Zanjani, Bamdad
Omidkhoda, Seyed Navid
Barangi, Samira
Karimi, Gholamreza
The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia
title The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia
title_full The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia
title_fullStr The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia
title_full_unstemmed The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia
title_short The hematopoietic potential of methanolic and aqueous extracts of Portulaca oleracea in a phenylhydrazine model of anemia
title_sort hematopoietic potential of methanolic and aqueous extracts of portulaca oleracea in a phenylhydrazine model of anemia
topic Original Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840774/
https://www.ncbi.nlm.nih.gov/pubmed/36698739
http://dx.doi.org/10.22038/AJP.2022.20965
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