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Ideal cardiovascular health metrics and the risk of nonalcoholic fatty liver disease in Korean adults

BACKGROUND: The association between cardiovascular risk factors and nonalcoholic fatty liver disease (NAFLD) is well established, but whether cardiovascular health (CVH) metrics is associated with NAFLD had not been fully studied. Thus, we examined the association between CVH metrics and NAFLD in th...

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Autores principales: Shim, Sun Young, Jung, Sun Jae, Kim, Seung Up, Kim, Hyeon Chang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840828/
https://www.ncbi.nlm.nih.gov/pubmed/36641485
http://dx.doi.org/10.1186/s40885-022-00227-0
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author Shim, Sun Young
Jung, Sun Jae
Kim, Seung Up
Kim, Hyeon Chang
author_facet Shim, Sun Young
Jung, Sun Jae
Kim, Seung Up
Kim, Hyeon Chang
author_sort Shim, Sun Young
collection PubMed
description BACKGROUND: The association between cardiovascular risk factors and nonalcoholic fatty liver disease (NAFLD) is well established, but whether cardiovascular health (CVH) metrics is associated with NAFLD had not been fully studied. Thus, we examined the association between CVH metrics and NAFLD in the middle-aged Korean population. METHODS: We used data of 2,928 (851 men and 2,077 women) participants aged 30–64 years from the Cardiovascular and Metabolic Disease Etiology Research Center study. CVH metrics were measured using a modified version of Life’s Simple 7 by the American Heart Association. NAFLD diagnosis was based on the fatty liver index or liver-to-spleen ratio on computed tomography. A multiple logistic regression model was used to investigate the cross-sectional and longitudinal associations between CVH metrics and NAFLD. RESULTS: In the cross-sectional analysis, the odds ratio for NAFLD was lower in participants with ideal CVH (odds ratio [OR], 0.13; 95% confidence interval [CI], 0.08–0.18), while it was higher in individuals with poor CVH (OR, 2.87; 95% CI, 2.13–3.86). Similarly, the risk of new-onset NAFLD was lower in participants with ideal CVH (OR, 0.28; 95% CI, 0.11–0.74), and higher in individuals with poor CVH (OR, 2.20; 95% CI, 0.50–9.72) in the longitudinal analysis of a subgroup. CONCLUSIONS: Ideal CVH was associated with a lower risk of NAFLD while poor CVH was associated with a higher risk of NAFLD. These findings suggest that making efforts to encourage people to manage their CVH to the ideal level may prevent and manage NAFLD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40885-022-00227-0.
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spelling pubmed-98408282023-01-16 Ideal cardiovascular health metrics and the risk of nonalcoholic fatty liver disease in Korean adults Shim, Sun Young Jung, Sun Jae Kim, Seung Up Kim, Hyeon Chang Clin Hypertens Research BACKGROUND: The association between cardiovascular risk factors and nonalcoholic fatty liver disease (NAFLD) is well established, but whether cardiovascular health (CVH) metrics is associated with NAFLD had not been fully studied. Thus, we examined the association between CVH metrics and NAFLD in the middle-aged Korean population. METHODS: We used data of 2,928 (851 men and 2,077 women) participants aged 30–64 years from the Cardiovascular and Metabolic Disease Etiology Research Center study. CVH metrics were measured using a modified version of Life’s Simple 7 by the American Heart Association. NAFLD diagnosis was based on the fatty liver index or liver-to-spleen ratio on computed tomography. A multiple logistic regression model was used to investigate the cross-sectional and longitudinal associations between CVH metrics and NAFLD. RESULTS: In the cross-sectional analysis, the odds ratio for NAFLD was lower in participants with ideal CVH (odds ratio [OR], 0.13; 95% confidence interval [CI], 0.08–0.18), while it was higher in individuals with poor CVH (OR, 2.87; 95% CI, 2.13–3.86). Similarly, the risk of new-onset NAFLD was lower in participants with ideal CVH (OR, 0.28; 95% CI, 0.11–0.74), and higher in individuals with poor CVH (OR, 2.20; 95% CI, 0.50–9.72) in the longitudinal analysis of a subgroup. CONCLUSIONS: Ideal CVH was associated with a lower risk of NAFLD while poor CVH was associated with a higher risk of NAFLD. These findings suggest that making efforts to encourage people to manage their CVH to the ideal level may prevent and manage NAFLD. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s40885-022-00227-0. BioMed Central 2023-01-15 /pmc/articles/PMC9840828/ /pubmed/36641485 http://dx.doi.org/10.1186/s40885-022-00227-0 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Shim, Sun Young
Jung, Sun Jae
Kim, Seung Up
Kim, Hyeon Chang
Ideal cardiovascular health metrics and the risk of nonalcoholic fatty liver disease in Korean adults
title Ideal cardiovascular health metrics and the risk of nonalcoholic fatty liver disease in Korean adults
title_full Ideal cardiovascular health metrics and the risk of nonalcoholic fatty liver disease in Korean adults
title_fullStr Ideal cardiovascular health metrics and the risk of nonalcoholic fatty liver disease in Korean adults
title_full_unstemmed Ideal cardiovascular health metrics and the risk of nonalcoholic fatty liver disease in Korean adults
title_short Ideal cardiovascular health metrics and the risk of nonalcoholic fatty liver disease in Korean adults
title_sort ideal cardiovascular health metrics and the risk of nonalcoholic fatty liver disease in korean adults
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840828/
https://www.ncbi.nlm.nih.gov/pubmed/36641485
http://dx.doi.org/10.1186/s40885-022-00227-0
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