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Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis
BACKGROUND/AIMS: There are no data regarding the association between sarcopenic obesity status and nonalcoholic fatty liver disease (NAFLD) and NAFLD-associated liver fibrosis. Therefore, we aimed to investigate the relationship between sarcopenic obesity status (sarcopenia only, obesity only, and s...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Editorial Office of Gut and Liver
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840924/ https://www.ncbi.nlm.nih.gov/pubmed/36472070 http://dx.doi.org/10.5009/gnl220041 |
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author | Song, Wolhwa Yoo, Sung Hwan Jang, Jinsun Baik, Su Jung Lee, Byoung Kwon Lee, Hyun Woong Park, Jong Suk |
author_facet | Song, Wolhwa Yoo, Sung Hwan Jang, Jinsun Baik, Su Jung Lee, Byoung Kwon Lee, Hyun Woong Park, Jong Suk |
author_sort | Song, Wolhwa |
collection | PubMed |
description | BACKGROUND/AIMS: There are no data regarding the association between sarcopenic obesity status and nonalcoholic fatty liver disease (NAFLD) and NAFLD-associated liver fibrosis. Therefore, we aimed to investigate the relationship between sarcopenic obesity status (sarcopenia only, obesity only, and sarcopenic obesity) and NAFLD and liver fibrosis in Korean adults. METHODS: In total, 2,191 subjects completed a health checkup program, including abdominal ultrasonography and FibroScan. Subjects were classified into the following four categories optimal body composition (nonobese and nonsarcopenic), sarcopenia only (nonobese), obesity only (nonsarcopenic), and sarcopenic obesity. Sarcopenic obesity was stratified by the skeletal muscle mass index and body fat using bioelectrical impedance analysis. NAFLD was diagnosed by ultrasonography, and liver fibrosis was assessed using transient elastography in subjects with NAFLD. RESULTS: The prevalence of NAFLD and liver fibrosis significantly increased according to the sarcopenic obesity status. In the logistic regression analysis, after adjusting for multiple risk factors, the odds ratio (OR) for the risk of NAFLD was largest in the sarcopenic obesity group (OR, 3.68; 95% confidence interval [CI], 2.94 to 4.60), followed by the obesity only (OR, 2.25; 95% CI, 1.67 to 3.03) and sarcopenia only (OR, 1.92; 95% CI, 1.30 to 2.84) groups, when compared with the optimal group. Additionally, liver fibrosis was independently associated with sarcopenic obesity status (OR 4.69, 95% CI 1.95 to 11.29; OR 4.17, 95% CI 1.56 to 11.17; OR 3.80, 95% CI 0.86 to 16.75, respectively). CONCLUSIONS: These results demonstrated that sarcopenic obesity was independently associated with NAFLD and liver fibrosis and increased the risk of NAFLD and liver fibrosis more than obesity or sarcopenia alone. |
format | Online Article Text |
id | pubmed-9840924 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Editorial Office of Gut and Liver |
record_format | MEDLINE/PubMed |
spelling | pubmed-98409242023-01-30 Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis Song, Wolhwa Yoo, Sung Hwan Jang, Jinsun Baik, Su Jung Lee, Byoung Kwon Lee, Hyun Woong Park, Jong Suk Gut Liver Original Article BACKGROUND/AIMS: There are no data regarding the association between sarcopenic obesity status and nonalcoholic fatty liver disease (NAFLD) and NAFLD-associated liver fibrosis. Therefore, we aimed to investigate the relationship between sarcopenic obesity status (sarcopenia only, obesity only, and sarcopenic obesity) and NAFLD and liver fibrosis in Korean adults. METHODS: In total, 2,191 subjects completed a health checkup program, including abdominal ultrasonography and FibroScan. Subjects were classified into the following four categories optimal body composition (nonobese and nonsarcopenic), sarcopenia only (nonobese), obesity only (nonsarcopenic), and sarcopenic obesity. Sarcopenic obesity was stratified by the skeletal muscle mass index and body fat using bioelectrical impedance analysis. NAFLD was diagnosed by ultrasonography, and liver fibrosis was assessed using transient elastography in subjects with NAFLD. RESULTS: The prevalence of NAFLD and liver fibrosis significantly increased according to the sarcopenic obesity status. In the logistic regression analysis, after adjusting for multiple risk factors, the odds ratio (OR) for the risk of NAFLD was largest in the sarcopenic obesity group (OR, 3.68; 95% confidence interval [CI], 2.94 to 4.60), followed by the obesity only (OR, 2.25; 95% CI, 1.67 to 3.03) and sarcopenia only (OR, 1.92; 95% CI, 1.30 to 2.84) groups, when compared with the optimal group. Additionally, liver fibrosis was independently associated with sarcopenic obesity status (OR 4.69, 95% CI 1.95 to 11.29; OR 4.17, 95% CI 1.56 to 11.17; OR 3.80, 95% CI 0.86 to 16.75, respectively). CONCLUSIONS: These results demonstrated that sarcopenic obesity was independently associated with NAFLD and liver fibrosis and increased the risk of NAFLD and liver fibrosis more than obesity or sarcopenia alone. Editorial Office of Gut and Liver 2023-01-15 2022-12-06 /pmc/articles/PMC9840924/ /pubmed/36472070 http://dx.doi.org/10.5009/gnl220041 Text en Copyright © Gut and Liver. https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0 (https://creativecommons.org/licenses/by-nc/4.0/) ) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Song, Wolhwa Yoo, Sung Hwan Jang, Jinsun Baik, Su Jung Lee, Byoung Kwon Lee, Hyun Woong Park, Jong Suk Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis |
title | Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis |
title_full | Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis |
title_fullStr | Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis |
title_full_unstemmed | Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis |
title_short | Association between Sarcopenic Obesity Status and Nonalcoholic Fatty Liver Disease and Fibrosis |
title_sort | association between sarcopenic obesity status and nonalcoholic fatty liver disease and fibrosis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840924/ https://www.ncbi.nlm.nih.gov/pubmed/36472070 http://dx.doi.org/10.5009/gnl220041 |
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