Identification of an inhibitory domain in GTPase-activating protein p190RhoGAP responsible for masking its functional GAP domain

The GTPase-activating protein (GAP) p190RhoGAP (p190A) is encoded by ARHGAP35 which is found mutated in cancers. p190A is a negative regulator of the GTPase RhoA in cells and must be targeted to RhoA-dependent actin-based structures to fulfill its roles. We previously identified a functional region...

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Detalles Bibliográficos
Autores principales: Héraud, Capucine, Pinault, Mathilde, Neaud, Véronique, Saltel, Frédéric, Lagrée, Valérie, Moreau, Violaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
JBC Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840978/
https://www.ncbi.nlm.nih.gov/pubmed/36516886
http://dx.doi.org/10.1016/j.jbc.2022.102792

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840978/
https://www.ncbi.nlm.nih.gov/pubmed/36516886
http://dx.doi.org/10.1016/j.jbc.2022.102792

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