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Identification of an inhibitory domain in GTPase-activating protein p190RhoGAP responsible for masking its functional GAP domain
The GTPase-activating protein (GAP) p190RhoGAP (p190A) is encoded by ARHGAP35 which is found mutated in cancers. p190A is a negative regulator of the GTPase RhoA in cells and must be targeted to RhoA-dependent actin-based structures to fulfill its roles. We previously identified a functional region...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Biochemistry and Molecular Biology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9840978/ https://www.ncbi.nlm.nih.gov/pubmed/36516886 http://dx.doi.org/10.1016/j.jbc.2022.102792 |