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Preferential formation of human heteromeric SK2:SK3 channels limits homomeric SK channel assembly and function

Three isoforms of small conductance, calcium-activated potassium (SK) channel subunits have been identified (SK1-3) that exhibit a broad and overlapping tissue distribution. SK channels have been implicated in several disease states including hypertension and atrial fibrillation, but therapeutic tar...

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Detalles Bibliográficos
Autores principales: Butler, Andrew S., Hancox, Jules C., Marrion, Neil V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841042/
https://www.ncbi.nlm.nih.gov/pubmed/36502918
http://dx.doi.org/10.1016/j.jbc.2022.102783