Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity

OBJECTIVE: Obesity and nutrient oversupply increase mammalian target of rapamycin (mTOR) signaling in multiple cell types and organs, contributing to the onset of insulin resistance and complications of metabolic disease. However, it remains unclear when and where mTOR activation mediates these effe...

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Detalles Bibliográficos
Autores principales: Brazill, Jennifer M., Shin, David, Magee, Kristann, Majumdar, Anurag, Shen, Ivana R., Cavalli, Valeria, Scheller, Erica L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841058/
https://www.ncbi.nlm.nih.gov/pubmed/36586433
http://dx.doi.org/10.1016/j.molmet.2022.101664

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841058/
https://www.ncbi.nlm.nih.gov/pubmed/36586433
http://dx.doi.org/10.1016/j.molmet.2022.101664

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