Cargando…

Knockout of TSC2 in Nav1.8+ neurons predisposes to the onset of normal weight obesity

OBJECTIVE: Obesity and nutrient oversupply increase mammalian target of rapamycin (mTOR) signaling in multiple cell types and organs, contributing to the onset of insulin resistance and complications of metabolic disease. However, it remains unclear when and where mTOR activation mediates these effe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Brazill, Jennifer M., Shin, David, Magee, Kristann, Majumdar, Anurag, Shen, Ivana R., Cavalli, Valeria, Scheller, Erica L.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Elsevier 2022
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841058/ https://www.ncbi.nlm.nih.gov/pubmed/36586433 http://dx.doi.org/10.1016/j.molmet.2022.101664

Ejemplares similares

SAT650 Catecholamine-independent Neural Pathways Drive The Rapid Catabolism Of Metabolically Inert Fat
por: Zhang, Xiao, et al.
Publicado: (2023)

Neuroskeletal Effects of Chronic Bioelectric Nerve Stimulation in Health and Diabetes
por: Beeve, Alec T., et al.
Publicado: (2021)

Animal Toxins Can Alter the Function of Nav1.8 and Nav1.9
por: Gilchrist, John, et al.
Publicado: (2012)

Nav1.7 and Nav1.8: Diabetes-induced Changes in Primary Sensory Neurons in Rats
por: Lv, Jianlin, et al.
Publicado: (2016)

PT707. Transcriptome analysis in Tsc2 heterozygous knockout mice
por: Kasai, Shinya, et al.
Publicado: (2016)

Loss of myeloid Tsc2 predisposes to angiotensin II-induced aortic aneurysm formation in mice
por: Liu, Xue, et al.
Publicado: (2022)

A Neuroskeletal Atlas: Spatial Mapping and Contextualization of Axon Subtypes Innervating the Long Bones of C3H and B6 Mice
por: Lorenz, Madelyn R, et al.
Publicado: (2021)

A bone-specific adipogenesis pathway in fat-free mice defines key origins and adaptations of bone marrow adipocytes with age and disease
por: Zhang, Xiao, et al.
Publicado: (2021)

Peripheral Neuropathy as a Component of Skeletal Disease in Diabetes
por: Beeve, Alec T., et al.
Publicado: (2019)

Chondrocyte-Specific Knockout of TSC-1 Leads to Congenital Spinal Deformity in Mice
por: Yang, Cheng, et al.
Publicado: (2017)

Mu Opioid Receptors on Primary Afferent Nav1.8 Neurons Contribute to Opiate-Induced Analgesia: Insight from Conditional Knockout Mice
por: Weibel, Raphaël, et al.
Publicado: (2013)

The TSC1-TSC2 complex consists of multiple TSC1 and TSC2 subunits
por: Hoogeveen-Westerveld, Marianne, et al.
Publicado: (2012)

Global Nav1.7 Knockout Mice Recapitulate the Phenotype of Human Congenital Indifference to Pain
por: Gingras, Jacinthe, et al.
Publicado: (2014)

Akt Phosphorylates Both Tsc1 and Tsc2 in Drosophila, but Neither Phosphorylation Is Required for Normal Animal Growth
por: Schleich, Sibylle, et al.
Publicado: (2009)

Properties of Nav1.8(ChR2)-positive and Nav1.8(ChR2)-negative afferent mechanoreceptors in the hindpaw glabrous skin of mice
por: Yamada, Akihiro, et al.
Publicado: (2023)

Correlation of Nav1.8 and Nav1.9 sodium channel expression with neuropathic pain in human subjects with lingual nerve neuromas
por: Bird, Emma V, et al.
Publicado: (2013)

Lidocaine reduces pain behaviors by inhibiting the expression of Nav1.7 and Nav1.8 and diminishing sympathetic sprouting in SNI rats
por: Li, Xiaoxiao, et al.
Publicado: (2022)

Electroacupuncture Reduces Carrageenan- and CFA-Induced Inflammatory Pain Accompanied by Changing the Expression of Nav1.7 and Nav1.8, rather than Nav1.9, in Mice Dorsal Root Ganglia
por: Huang, Chun-Ping, et al.
Publicado: (2013)

Increase of Sodium Channels (Nav 1.8 and Nav 1.9) in Rat Dorsal Root Ganglion Neurons Exposed to Autologous Nucleus Pulposus
por: Watanabe, Kazuyuki, et al.
Publicado: (2014)

Antihyperalgesic effects of ProTx-II, a Nav1.7 antagonist, and A803467, a Nav1.8 antagonist, in diabetic mice
por: Tanaka, Ken-ichiro, et al.
Publicado: (2015)

Numerical knockouts–In silico assessment of factors predisposing to thoracic aortic aneurysms
por: Latorre, M., et al.
Publicado: (2020)

SAT653 Conditional Knockout Of Neural Sarm1 Improves Body Mass And Metabolic Health With High Fat Diet
por: Dabill, Lila, et al.
Publicado: (2023)

Physiological and Pathophysiological Insights of Nav1.4 and Nav1.5 Comparison
por: Loussouarn, Gildas, et al.
Publicado: (2016)

Tsc2 knockout counteracts ubiquitin-proteasome system insufficiency and delays photoreceptor loss in retinitis pigmentosa
por: Wang, Yixiao, et al.
Publicado: (2022)

The Predisposing Factors between Dental Caries and Deviations from Normal Weight
por: Chopra, Amandeep, et al.
Publicado: (2015)

Left-Shifted Nav Channels in Injured Bilayer: Primary Targets for Neuroprotective Nav Antagonists?
por: Morris, Catherine E., et al.
Publicado: (2012)

Nerves in Bone: Evolving Concepts in Pain and Anabolism
por: Brazill, Jennifer M, et al.
Publicado: (2019)

Transiently Nav1.8-expressing neurons are capable of sensing noxious stimuli in the brain
por: Tenza-Ferrer, Helia, et al.
Publicado: (2022)

Nav1.8 in keratinocytes contributes to ROS-mediated inflammation in inflammatory skin diseases
por: Zhang, Yiya, et al.
Publicado: (2022)

Conditional knockout of Tsc1 in RORγt-expressing cells induces brain damage and early death in mice
por: Deng, Yafei, et al.
Publicado: (2021)

Mosaic and Intronic Mutations in TSC1/TSC2 Explain the Majority of TSC Patients with No Mutation Identified by Conventional Testing
por: Tyburczy, Magdalena E., et al.
Publicado: (2015)

Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2
por: Kwiatkowski, David J, et al.
Publicado: (2015)

Identification of Navβ1 Residues Involved in the Modulation of the Sodium Channel Nav1.4
por: Islas, Angel A., et al.
Publicado: (2013)

German Language Adaptation of the NAVS (NAVS-G) and of the NAT (NAT-G): Testing Grammar in Aphasia
por: Ditges, Ruth, et al.
Publicado: (2021)

Evidence for population variation in TSC1 and TSC2 gene expression
por: Jentarra, Garilyn M, et al.
Publicado: (2011)

Bone marrow adipose tissue does not express UCP1 during development or adrenergic-induced remodeling
por: Craft, Clarissa S., et al.
Publicado: (2019)

Deletion of Tsc2 in Nociceptors Reduces Target Innervation, Ion Channel Expression, and Sensitivity to Heat
por: Carlin, Dan, et al.
Publicado: (2018)

Contrasting Nav1.8 Activity in Scn10a (−/−) Ventricular Myocytes and the Intact Heart
por: Stroud, Dina Myers, et al.
Publicado: (2016)

MicroRNA-18 promotes apoptosis of islet β-cells via targeting NAV1
por: Fei, Honghua, et al.
Publicado: (2019)

mTORC1 Activation in Chx10-Specific Tsc1 Knockout Mice Accelerates Retina Aging and Degeneration
por: Rao, Yu-Qing, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_rcq2cesb2518kr201oka1dpcu0