Cargando…
Neutrophil Infiltration and Acinar-ductal Metaplasia Are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis
The histopathological findings of immune checkpoint inhibitor (ICI)-induced pancreatitis have rarely been reported. A 56-year-old man with squamous cell carcinoma of the lung with bone metastasis was being treated with pembrolizumab, an anti-programmed cell death protein-1 antibody. After 13 doses,...
Autores principales: | , , , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Japanese Society of Internal Medicine
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841103/ https://www.ncbi.nlm.nih.gov/pubmed/35527030 http://dx.doi.org/10.2169/internalmedicine.9565-22 |
_version_ | 1784869758390239232 |
---|---|
author | Hirota, Morihisa Murakami, Keigo Koiwai, Akinobu Kawamura, Keita Yoshino, Yuki Takasu, Atsuko Kin, Ryo Katayama, Tomofumi Endo, Katsuya Kogure, Takayuki Meguro, Takayoshi Tabata, Toshiharu Murakami, Kazuhiro Satoh, Kennichi |
author_facet | Hirota, Morihisa Murakami, Keigo Koiwai, Akinobu Kawamura, Keita Yoshino, Yuki Takasu, Atsuko Kin, Ryo Katayama, Tomofumi Endo, Katsuya Kogure, Takayuki Meguro, Takayoshi Tabata, Toshiharu Murakami, Kazuhiro Satoh, Kennichi |
author_sort | Hirota, Morihisa |
collection | PubMed |
description | The histopathological findings of immune checkpoint inhibitor (ICI)-induced pancreatitis have rarely been reported. A 56-year-old man with squamous cell carcinoma of the lung with bone metastasis was being treated with pembrolizumab, an anti-programmed cell death protein-1 antibody. After 13 doses, he was referred to our department due to pancreatitis. Despite characteristic symptoms of acute pancreatitis, imaging findings were similar to those of autoimmune pancreatitis. However, a histological examination showed neutrophil-based inflammatory cell infiltration and acinar-ductal metaplasia. Immunostaining showed CD8-positive T lymphocyte infiltration. This case revealed the characteristic histopathology of pembrolizumab-induced pancreatitis, which was previously poorly understood. |
format | Online Article Text |
id | pubmed-9841103 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | The Japanese Society of Internal Medicine |
record_format | MEDLINE/PubMed |
spelling | pubmed-98411032023-01-26 Neutrophil Infiltration and Acinar-ductal Metaplasia Are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis Hirota, Morihisa Murakami, Keigo Koiwai, Akinobu Kawamura, Keita Yoshino, Yuki Takasu, Atsuko Kin, Ryo Katayama, Tomofumi Endo, Katsuya Kogure, Takayuki Meguro, Takayoshi Tabata, Toshiharu Murakami, Kazuhiro Satoh, Kennichi Intern Med Case Report The histopathological findings of immune checkpoint inhibitor (ICI)-induced pancreatitis have rarely been reported. A 56-year-old man with squamous cell carcinoma of the lung with bone metastasis was being treated with pembrolizumab, an anti-programmed cell death protein-1 antibody. After 13 doses, he was referred to our department due to pancreatitis. Despite characteristic symptoms of acute pancreatitis, imaging findings were similar to those of autoimmune pancreatitis. However, a histological examination showed neutrophil-based inflammatory cell infiltration and acinar-ductal metaplasia. Immunostaining showed CD8-positive T lymphocyte infiltration. This case revealed the characteristic histopathology of pembrolizumab-induced pancreatitis, which was previously poorly understood. The Japanese Society of Internal Medicine 2022-05-07 2022-12-15 /pmc/articles/PMC9841103/ /pubmed/35527030 http://dx.doi.org/10.2169/internalmedicine.9565-22 Text en Copyright © 2022 by The Japanese Society of Internal Medicine https://creativecommons.org/licenses/by-nc-nd/4.0/The Internal Medicine is an Open Access journal distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License. To view the details of this license, please visit (https://creativecommons.org/licenses/by-nc-nd/4.0/). |
spellingShingle | Case Report Hirota, Morihisa Murakami, Keigo Koiwai, Akinobu Kawamura, Keita Yoshino, Yuki Takasu, Atsuko Kin, Ryo Katayama, Tomofumi Endo, Katsuya Kogure, Takayuki Meguro, Takayoshi Tabata, Toshiharu Murakami, Kazuhiro Satoh, Kennichi Neutrophil Infiltration and Acinar-ductal Metaplasia Are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis |
title | Neutrophil Infiltration and Acinar-ductal Metaplasia Are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis |
title_full | Neutrophil Infiltration and Acinar-ductal Metaplasia Are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis |
title_fullStr | Neutrophil Infiltration and Acinar-ductal Metaplasia Are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis |
title_full_unstemmed | Neutrophil Infiltration and Acinar-ductal Metaplasia Are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis |
title_short | Neutrophil Infiltration and Acinar-ductal Metaplasia Are the Main Pathological Findings in Pembrolizumab-induced Pancreatitis |
title_sort | neutrophil infiltration and acinar-ductal metaplasia are the main pathological findings in pembrolizumab-induced pancreatitis |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841103/ https://www.ncbi.nlm.nih.gov/pubmed/35527030 http://dx.doi.org/10.2169/internalmedicine.9565-22 |
work_keys_str_mv | AT hirotamorihisa neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT murakamikeigo neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT koiwaiakinobu neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT kawamurakeita neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT yoshinoyuki neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT takasuatsuko neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT kinryo neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT katayamatomofumi neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT endokatsuya neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT koguretakayuki neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT megurotakayoshi neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT tabatatoshiharu neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT murakamikazuhiro neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis AT satohkennichi neutrophilinfiltrationandacinarductalmetaplasiaarethemainpathologicalfindingsinpembrolizumabinducedpancreatitis |