Subclonal evolution and expansion of spatially distinct THY1-positive cells is associated with recurrence in glioblastoma

PURPOSE: Glioblastoma(GBM) is a lethal disease characterized by inevitable recurrence. Here we investigate the molecular pathways mediating resistance, with the goal of identifying novel therapeutic opportunities. EXPERIMENTAL DESIGN: We developed a longitudinal in vivo recurrence model utilizing pa...

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Detalles Bibliográficos
Autores principales: Al-Holou, Wajd N., Wang, Hanxiao, Ravikumar, Visweswaran, Shankar, Sunita, Oneka, Morgan, Fehmi, Ziad, Verhaak, Roel GW, Kim, Hoon, Pratt, Drew, Camelo-Piragua, Sandra, Speers, Corey, Wahl, Daniel R, Hollon, Todd, Sagher, Oren, Heth, Jason A, Muraszko, Karin M., Lawrence, Theodore S., de Carvalho, Ana C, Mikkelsen, Tom, Rao, Arvind, Rehemtulla, Alnawaz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841165/
https://www.ncbi.nlm.nih.gov/pubmed/36621024
http://dx.doi.org/10.1016/j.neo.2022.100872

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