FRTX-02, a selective and potent inhibitor of DYRK1A, modulates inflammatory pathways in mouse models of psoriasis and atopic dermatitis

Dual-specificity tyrosine phosphorylation-regulated kinase 1 A (DYRK1A) has been proposed as a novel regulator of adaptive immune homeostasis through modulating T cell polarization. Thus, DYRK1A could present a potential target in autoimmune disorders. Here, we identify FRTX-02 as a novel compound e...

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Detalles Bibliográficos
Autores principales: Kim, Soochan, Ko, Eunhwa, Choi, Hwan Geun, Kim, Daekwon, Luchi, Monica, Khor, Bernard, Kim, Sunghwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Research paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841288/
https://www.ncbi.nlm.nih.gov/pubmed/36654851
http://dx.doi.org/10.1016/j.jtauto.2022.100185

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