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ST3GAL5‐catalyzed gangliosides inhibit TGF‐β‐induced epithelial‐mesenchymal transition via TβRI degradation

Epithelial‐mesenchymal transition (EMT) is pivotal in the initiation and development of cancer cell metastasis. We observed that the abundance of glycosphingolipids (GSLs), especially ganglioside subtypes, decreased significantly during TGF‐β‐induced EMT in NMuMG mouse mammary epithelial cells and A...

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Detalles Bibliográficos
Autores principales: Zhang, Jing, van der Zon, Gerard, Ma, Jin, Mei, Hailiang, Cabukusta, Birol, Agaser, Cedrick C, Madunić, Katarina, Wuhrer, Manfred, Zhang, Tao, ten Dijke, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841337/
https://www.ncbi.nlm.nih.gov/pubmed/36504224
http://dx.doi.org/10.15252/embj.2021110553