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Tau as a fluid biomarker of concussion and neurodegeneration

Concussion is predominant among the vast number of traumatic brain injuries that occur worldwide. Difficulties in timely identification, whether concussion led to neuronal injury or not, diagnosis and the lack of prognostic tools for adequate management could lead this type of brain injury to progre...

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Autores principales: Hossain, Iftakher, Blennow, Kaj, Posti, Jussi P, Zetterberg, Henrik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Future Medicine Ltd 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841393/
https://www.ncbi.nlm.nih.gov/pubmed/36687115
http://dx.doi.org/10.2217/cnc-2022-0004
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author Hossain, Iftakher
Blennow, Kaj
Posti, Jussi P
Zetterberg, Henrik
author_facet Hossain, Iftakher
Blennow, Kaj
Posti, Jussi P
Zetterberg, Henrik
author_sort Hossain, Iftakher
collection PubMed
description Concussion is predominant among the vast number of traumatic brain injuries that occur worldwide. Difficulties in timely identification, whether concussion led to neuronal injury or not, diagnosis and the lack of prognostic tools for adequate management could lead this type of brain injury to progressive neurodegenerative diseases. Tau has been extensively studied in recent years, particularly in repetitive mild traumatic brain injuries and sports-related concussions. Tauopathies, the group of neurodegenerative diseases, have also been studied with advanced functional imaging. Nevertheless, neurodegenerative diseases, such as chronic traumatic encephalopathy, are still conclusively diagnosed at autopsy. Here, we discuss the diagnostic dilemma and the relationship between concussion and neurodegenerative diseases and review the literature on tau as a promising biomarker for concussion.
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spelling pubmed-98413932023-01-20 Tau as a fluid biomarker of concussion and neurodegeneration Hossain, Iftakher Blennow, Kaj Posti, Jussi P Zetterberg, Henrik Concussion Review Concussion is predominant among the vast number of traumatic brain injuries that occur worldwide. Difficulties in timely identification, whether concussion led to neuronal injury or not, diagnosis and the lack of prognostic tools for adequate management could lead this type of brain injury to progressive neurodegenerative diseases. Tau has been extensively studied in recent years, particularly in repetitive mild traumatic brain injuries and sports-related concussions. Tauopathies, the group of neurodegenerative diseases, have also been studied with advanced functional imaging. Nevertheless, neurodegenerative diseases, such as chronic traumatic encephalopathy, are still conclusively diagnosed at autopsy. Here, we discuss the diagnostic dilemma and the relationship between concussion and neurodegenerative diseases and review the literature on tau as a promising biomarker for concussion. Future Medicine Ltd 2022-12-06 /pmc/articles/PMC9841393/ /pubmed/36687115 http://dx.doi.org/10.2217/cnc-2022-0004 Text en © 2022 Iftakher Hossain https://creativecommons.org/licenses/by/4.0/This work is licensed under the Creative Commons Attribution 4.0 License (https://creativecommons.org/licenses/by/4.0/)
spellingShingle Review
Hossain, Iftakher
Blennow, Kaj
Posti, Jussi P
Zetterberg, Henrik
Tau as a fluid biomarker of concussion and neurodegeneration
title Tau as a fluid biomarker of concussion and neurodegeneration
title_full Tau as a fluid biomarker of concussion and neurodegeneration
title_fullStr Tau as a fluid biomarker of concussion and neurodegeneration
title_full_unstemmed Tau as a fluid biomarker of concussion and neurodegeneration
title_short Tau as a fluid biomarker of concussion and neurodegeneration
title_sort tau as a fluid biomarker of concussion and neurodegeneration
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9841393/
https://www.ncbi.nlm.nih.gov/pubmed/36687115
http://dx.doi.org/10.2217/cnc-2022-0004
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